Hepatocyte growth factor(HGF) is a pleiotropic factor, which plays an important role in the nervous system. 肝细胞生长因子(hepatocyte growth factor,HGF)是一个多效应因子,在神经系统中具有重要作用。 更多例句>> 4) serum ferritin SF 1. The clinical significance of measuringserum ferritinandβ_2-Micr...
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HGF/SF Dictionary, Encyclopedia and Thesaurus - The Free Dictionary13,852,714,799visits served TheFreeDictionary Google ? Keyboard Word / Article Starts with Ends with Text EnglishEspañolDeutschFrançaisItalianoالعربية中文简体PolskiPortuguêsNederlandsNorskΕλληνικήРус...
Bottaro等[4]提出HGF/SF作为MET的配体,发现通过靶向敲除小鼠Hgf和MET基因得到证实,对这些变异小鼠的研究提示了Hgf和MET基因所编码的蛋白在不同细胞与组织的生存,生长及迁移中的重要生理作用. HGF/SF-MET信号系统标志特征是MET蛋白所激活的细胞反应的多样性,它由该信号系统MET下游停泊蛋白--生长因子受体结合蛋白2(GR...
Figure 1.Following binding of HGF/SF, MET receptor signaling can modulate integrin function by promoting aggregation of integrins and adhesion to integrin-specific ligands. Integrins and growth factor receptors can share common signaling pathways.1,2Each type of receptor can impact the signal and ulti...
Hepatocyte growth factor/scatter factor (HGF/SF) is a mesenchyme-derived cytokine that stimulates motility and invasiveness of epithelial and cancer cells. These responses are transduced through the c-met proto-oncogene product, a transmembrane tyrosine kinase that functions as the HGF/SF receptor. We...
1 HGF/SF MET 通路的基本机制 HGF/SF 引起 MET 的二聚化,通过酪氨酸残基(Tyr1230、 Tyr1234、Tyr1235)的磷酸化激活了受体胞内蛋白激酶结构域中 酪氨酸激酶(PTK),激活的PTK 先使受体自身的酪氨酸残基磷 酸化, 进而引起 MET 羧基末端 Tyr1349 和 Tyr1356 自磷酸 ...
锤头状核酶靶向抑制HGF／SF的受体c—Met表达可降低前列腺癌细胞的体外侵袭和转移
慢性肾炎患者输注红细胞前后SF、血清VEGF和HGF水平及临床意义
HGF/SF—MET通路的基本原理 来自维普期刊专业版 作者苏会玲,汤桂梅,范洪君,苏红慧,陈坤摘要 20世纪80年代中期,MET和它的配体肝细胞生长和离散因子( HGF/SF)相继被3个独立的研究机构发现。 MET基因最早在人的骨肉瘤细胞中克隆[1],随后发现原癌基因MET编码受体酪氨酸...