Validation of Cre-excision in SF1-expressing neurons in the VMH.Barbara, BaldoRachel, Y. CheongÅsa, Petersén
Here we investigated the importance of the autophagy-related gene Atg7 in Sf1-expressing neurons of the VMH in control and fasted conditions. Methods We generated Sf1-Cre; Atg7loxP/loxP mice and examined their metabolic and cellular response to fasting. Results Fasting induces autophagy in the ...
They also had impaired expression of pituitary gonadotropins and agenesis of the ventromedial hypothalamic nucleus (VMH), confirming roles of SF-1 at multiple levels of the hypothalamic-pituitary-steroidogenic tissue axis. Using the Cre-loxP system, we now have generated mice in which SF-1 is ...
Here, we evaluate EE and muscle thermogenesis in SF1-Cre mice exposed to PO (ferret odor) compared to transgenic and viral controls. We detected significant increases in muscle temperature, EE, and oxygen consumption following the chemogenetic stimulation of SF1 cells. However,...