9 OT+ PVN neurons innervate dopaminergic circuitry in a sexually dimorphic manner. a,b, Quantification of OT+ PVN anterograde projections to various brain regions of wild-BX mice following the semi-natural expe
1993. Sexually dimor- phic effects of aging on tuberoinfundibular dopaminergic neurons and lactotropes of rats. Mech Ageing Dev 72: 129 - 143.G.L. Rossi, G.E. Bestetti and R. Neiger, Sexually dimorphic effects of aging on tuberoinfundibular dopaminergic neurons and lactotrops of rats. ...
We now extend these findings to include potential sex-dependent dopaminergic system dysfunctions at a very early stage of the disease (i.e. 8 weeks of age). In this present study, we show that female (but not male) HD animals were less responsive to the effect of the dopamine–...
. For the relevant neuronal populations, we expressed either a membrane tagged GFP (UAS-FRT-stop-FRT-mCD8::GFP) to visualize the arborizations of the neurons or the neuronal silencer tetanus toxin (UAS-FRT-stop-FRT-TNT) to block neuronal activity. Previously, we identified a cluster of ...
Even for common pathways, the specific target mRNAs are often sexually dimorphic. For example, both male and female target genes significantly populate the Axonal Guidance Signaling pathway, yet less than a third of the targets are common to both sexes. Conclusions: Our findings of sexual ...
Prolactin (PRL) is a pleiotropic hormone that was identified in the context of maternal care and whose release from the anterior pituitary is primarily controlled by Neuroendocrine Dopaminergic (NEDA) neurons of the Arcuate Nucleus of the Hypothalamus. The sexually dimorphic nature of PRL physiology ...
The results also show that the response circuits differ depending on the stressor and behavioral output. Furthermore, the authors' studies provide a translatable Drosophila model for further elucidation of factors involved in the sexually dimorphic recruitment of neurons into the stress response circuitry...
doi:10.3390/brainsci7010005Glenda GilliesKanwar VirdeeIlse PienaarJeffrey DalleyMDPIGillies GE et al. Enduring, sexually dimorphic impact of in utero exposure to elevated lev- els of glucocorticoids on midbrain dopaminergic populations. Brain Sciences. 2016;7(1)...
Wilson CA, Dakin CL, Rico JA, Golmohamad A, Ahmad-Jauhari Y, Davies DC. The anti- dopaminergic agent, haloperidol, antagonises the feminising effect of neonatal sero- tonin on sexually dimorphic hypothalamic nuclei and tyrosine hydroxylase immu- noreactive neurones. J Neuroendocrinol 2009;21:...
However, OxtrINs produce two mechanistically distinct modulatory substances, GABA and CRHBP, which act on local circuits in the mPFC to regulate behavior differentially. They do so because their function requires the sexually dimorphic hypothalamic hormones OXT and CRH and because of the restricted ...