However, a male with a recessive allele for a gene unique to the X chromosome will always exhibit that recessive trait because there is no other corresponding allele on the Y chromosome. In humans, each of two different sex-linked genes has a defective recessive allele that causes a disease....
In humans, the fraction of X-linked genes with higher expression in females has been estimated to be 5% from microarray studies, a proportion lower than the 25% of genes thought to escape X inactivation. We analyzed 715 X-linked transcripts in circulating monocytes from 1,467 subjects and fou...
Inheritance of most X-linked traits is not dominant or recessive, just X-linked The existence of X-linked disorders in humans has been recognized for many centuries, based on lessons in religious texts and observations of specific huma... WB Dobyns,F Allison,BN Tomson,... - 《American Journ...
It is important not to overlook men with autoimmune diseases, who might manifest a more frequent loss of the Y chromosome in circulating leukocytes. Taken together, sex chromosome changes might constitute the common trait of autoimmunity. 展开 ...
Genetic Determinants of Long-Term Changes in Blood Lipid Concentrations:. Recent genome-wide meta-analyses identified 157 loci associated with cross-sectional lipid traits. Here we tested whether these loci associate (singly and in trait-specific genetic risk scores [GRS]) with longitudinal changes in...
Genome-wide association mapping in a wild avian population identifies a link between genetic and phenotypic variation in a life-history trait not significant, although there was some indication of a sex-by-genotype interaction for lifetime reproductive success at the suggestive QTL on chromosome ......
Genome-wide association mapping in a wild avian population identifies a link between genetic and phenotypic variation in a life-history trait Understanding the genetic basis of traits involved in adaptation is a major challenge in evolutionary biology but remains poorly understood. Here, we use g.....
Obesity is a heritable trait caused by complex interactions between genes and environment, including diet. Gene-by-diet interactions are difficult to study in humans because the human diet is hard to control. Here, we used mice to study dietary obesity genes, by four methods. First, we bred ...
Inheritance of most X-linked traits is not dominant or recessive, just X-linked The existence of X-linked disorders in humans has been recognized for many centuries, based on lessons in religious texts and observations of specific huma... WB Dobyns,F Allison,BN Tomson,... - 《American Journ...
Intralocus sexual conflict occurs when selection on a shared trait in one sex displaces the other sex from its phenotypic optimum. It arises because many s... R Bonduriansky,SF Chenoweth - 《Trends in Ecology & Evolution》 被引量: 865发表: 2009年 Widespread loss of sexually selected traits...