Sex differences in cancer and immunotherapy outcomes: the role of androgen receptordoi:10.3389/fimmu.2024.1416941ANDROGEN receptorsSEX chromosomesTUMOR microenvironmentGENDERCANCER prognosisAcross the wide range of clinical conditions, there exists a sex imbalance where biological females ...
Sexual dimorphism in cancer Two studies have now provided evidence of differences, dependent on patient sex, in oncogenic features, such as frequencies of driver gene mutations, mutation load and mutational signatures, as well as immune selection. ...
Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here ...
6.2: Sex differences in the immune system 6.3: Implications for immunotherapy Fig.4Sex differences in immune cells affecting cancer development 7. Angiogenesis 7.1: Angiogenesis and cancer 7.2: Sex differences in angiogenesis 7.3: Implications for targeting tumor angiogenesis Fi...
Kim, Hae-In,H Lim,A Moon 摘要: The incidence and mortality of various cancers are associated with sex-specific disparities. Sex differences in cancer epidemiology are one of the most significant findings. Men are more prone to die from cancer, particularly hematological malignancies. Sex ...
A new database could lead to vast improvements in precision oncology by documenting sex-based differences in cancer treatment efficacy, biomarkers, risk factors, and microbial influences across 71 cancer types. The database—created by researchers at the Yale School of Public Health (YSPH), Yale ...
Sex Differences in Cancer Genomes: Much Learned, More Unknown 来自 EBSCO 喜欢 0 阅读量: 10 作者:C Zhu,PC Boutros 摘要: Cancer is a leading cause of death worldwide. Sex influences cancer in a bewildering variety of ways. In some cancer types, it affects prevalence; in others, genomic ...
Sex-related differences in cancer epidemiology, tumor biology, immune system activity, and pharmacogenomics have been suggested to be important considerations for precision cancer control. Here we elucidated systematically sex biases in genetic variants, gene expression profiles, and immunological landscapes ...
Our primary objective was to determine whether the increase in cancer incidence among young individuals, stratified by sex and age, was specific to pancreatic cancer or if it extended to other malignancies. Secondly, we aimed to investigate sex differences in cancer incidence within young subgroups ...
A sexual dimorphism at the cellular level has been suggested to play a role in cancer onset and progression. In particular, very recent studies have unraveled striking differences between cells carrying XX or XY chromosomes in terms of response to stressful stimuli, indicating the presence of geneti...