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germ cell sexgoniameiosistroutGerm cells make two major decisions when they move from an indeterminate state to their final stage of gamete production.One decision is sexual commitment for sperm or egg production,and the other is to maintain mitotic division or entry into meiosis.It is unclear ...
Sex determination is an essential step in the commitment of a germ cell to a sperm or egg. However, the intrinsic factors that determine the sexual fate of vertebrate germ cells are unknown. Here, we show that foxl3, which is expressed in germ cells but not somatic cells in the gonad, ...
Sex determination mechanisms often differ even between related species yet the evolution of sex chromosomes remains poorly understood in all but a few model organisms. Some nematodes such asCaenorhabditis eleganshave an XO sex determination system while others, such as the filarial parasiteBrugia malayi...
since the translocation boundary overlaps theS. mansoniS0/PAR boundary. Within the Z-linked S0 region ofS. mansoni, we found the ortholog of theC. elegansgenemag-1, whose knockdown inC. eleganscauses the hermaphrodites to produce sperm instead of oocytes82; inS. japonicum, its knockdown causes...
The “translation” GO term uncovered enrichment for several ribosomal proteins also known to play an essential role in cell proliferation in response to ribosomal stress [60]. We also identified enrichment in molecular functions such as transferase activity indicative of possible post-transcriptional ...
One special example of sexual antagonistic pleiotropy involves heterogametic species (with egg and sperm), where the mitochondrial genome is preferentially inherited from the mother through the egg. This means that natural selection can only act in females to optimize mitochondrial gene functions and ...
mutations in many ribosomal protein genes result in female sterility due to defective egg formation [53]. The over-representation of transcripts from genes required for DNA replication may be required for nurse cell polyploidization or the rapid division of embryonic cells, which rely on maternally ...
Here, we describe a drug-inducible genetic system for insect sex-separation that demonstrates proof-of-principle for positive sex selection in D. melanogaster. The system exploits the toxicity of commonly used broad-spectrum antibiotics geneticin and pur
precisely revealing their 3D translational head motion and the angular velocity of their head spin as well as the 3D flagellar motion. Our results confirmed that various motility parameters remain similar between X- and Y-sorted sperm populations; however, we found out that there is a statistically...