SepsisBACKGROUND: In the setting of severe sepsis and septic shock, mortality increases when lactatelevels are ! 4 mmol/L. However, the consequences of lower lactate levels in this population are not wellunderstood. The study aimed to determine the in-hospital mortality associated with severe seps...
www.nature.com/scientificreports OPEN Clinical outcomes of severe sepsis and septic shock patients with left ventricular dysfunction undergoing continuous renal replacement therapy Guangwei Yu 1,6, Kun Cheng2,3,5, Qing Liu1, Wenwei Wu1, Huashan Hong4,6* & Xiaohong Lin...
The ProCESS, ARISE, and ProMISe trials have failed to show that early goal-directed therapy (EGDT) reduces mortality in patients with severe sepsis and septic shock. Although lactate-guided therapy (LGT) has been shown to result in significantly lower mortality, its use remains controversial. Ther...
The main manifestations of sepsis include gastrointestinal dysfunction or failure, and gastrointestinal mucosa injury, leading to the translocation of gastrointestinal bacteria and toxin and to septic shock3,4. Furthermore, aggravation of the septic shock condition will lead to the further impairment of ...
Recently, the gastrointestinal bacterial microbiome has been shown to be a key component in regulating the immune response and recovery from burn injury, and may also contribute to significant adverse sequelae after injury, such as sepsis and multiple organ failure [6]. There is clear evidence ...
However, even with intravenous artesunate, the mortality rate of adults with severe malaria in many Asian hospitals remains over 15%; the majority dying during the first 48 hours of their hospitalization [1]. Guidelines for the initial management of patients with sepsis make a series of ...
Rare(0.01% to 0.1%): Abscess, cellulitis, herpes zoster, peritonitis, sepsis Frequency not reported: Cold symptoms, flu syndrome HYDROCHLORIDE CR FORMULATIONS: Common(1% to 10%): Infection[Ref] Hepatic HYDROCHLORIDE IR/MESYLATE TABLET FORMULATIONS: ...
Rare(0.01% to 0.1%): Abscess, cellulitis, herpes zoster, peritonitis, sepsis Frequency not reported: Cold symptoms, flu syndrome HYDROCHLORIDE CR FORMULATIONS: Common(1% to 10%): Infection[Ref] Hepatic HYDROCHLORIDE IR/MESYLATE TABLET FORMULATIONS: ...
Frequency not reported: Chest pain, breast pain, breast enlargement, sepsis, ear pain, otitis externa, tinnitus, malaise, viral infection[Ref]Gastrointestinal Very common (10% or more): Diarrhea (up to 42%), nausea (up to 16%), vomiting (up to 13%), abdominal pain (up to 11%) Common...
and has been used in the critical care setting to guide the administration of replacement fluids. In the current Surviving Sepsis Guidelines, fluid resuscitation to achieve a CVP of 8-12 mmHg is one of the key recommendations [2]. Optimizing the fluid status of patients with severe malaria ...