Definition: Chronic renal failure is progressive and gradual loss of the kidneys' ability to excrete wastes, concentrate urine, and conserve electrolytes. Additional names: Kidney failure–chronic; renal failure–chronic; chronic renal insufficiency; CRF; chronic kidney failure Causes and risk fac...
Annemieke Cats8 and Jan H M Schellens1,2,5 1Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam 1066CX, The Netherlands; 2Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam 1066CX, The Netherlands; 3Department of Pha...
Animal models have an important role in determining virus transmission routes, screening effective drugs, and evaluating vaccine development. Currently, the animal models commonly used for COVID-19 mainly include rhesus macaques [7], cats [8], ferrets [8], hamsters [9] and mice. The mouse mode...
Minor lesions in the liver and kidney were also observed in the later stages of the infection with viremia peaking at day 5 ~105 TCID50/mL and clearing by day 7. Although the rhesus macaques used in that study did become infected, their disease progression mirrored that of only acute SFTSV...
Kidney failure in turn leads to azotemia;depending on the severity and duration of renal dysfunction, metabolic addosis, hyper-kalemia, and abnormal fluid balance may also develop, leading to cardiac damage and failure. Although this sequence of events is speculative, the findings at gross ...
The density of ACE2 in each tissue correlates with the severity of the COVID-19 disease in that tissue. As the disease progresses, respiratory failure and consequent death may occur (Xu et al., 2020). ACE2 is also attached to the outer surface of cells in the arteries, heart, kidney,...
Safety of SGLT2 Inhibitors in Three Chronic Diseases. This study aimed to assess the safety of SGLT2 inhibitors in type 2 diabetes, chronic kidney disease, and chronic heart failure considering the number need... S Ge,R Liu,Y Mao,... - 《International Heart Journal》 被引量: 0发表: 202...
But on her fourth day at the hospital, her symptoms got worse: She developed a headache, high fever, chills and diarrhea, and tests showed she had sudden kidney failure, the report said. She was admitted to the intensive care unit for severe sepsis— a potentially life-threatening complicatio...
(Fig.1c). High median tissue viral loads on day 2 of 1012RNA copies per gram in lung tissue and 108–109RNA copies per gram in nares and trachea were observed, with a median of 105–108RNA copies per gram in heart, gastrointestinal tract, brain, spleen, liver and kidney, indicative ...
Numerous risk factors are associated with fatal outcomes of SFTSV infections2,7,53. Several clinical presentations and abnormalities in laboratory parameters (such as respiratory failure, hemorrhagic manifestations, DIC, and liver and kidney dysfunction) have also been considered to contribute to poor pro...