COPDGeneticsCOPD - diagnosisIntroduction: Among those who develop severe COPD and advanced emphysema, a small subset of up to 2-3% possesses polymorphisms of the SERPINA1 gene, associated with alpha-1 antitrypsin deficiency (AATD). The current study aimed to identify the frequency of genetic ...
Pulmonary Rehabilitation in Severe EmphysemaChronic obstructive pulmonary disease (COPD) is the fourth most frequent cause of death in the United States, with an estimated national prevalence of 14 to 20 million persons (1). Chronic disability caused by COPD ranks second only to cardiac disease in...
Young J. Lung volume surgery (LVRS) for chronic obstructive pulmonary disease (COPD) with underlying severe emphysema, A West Midlands Development and ... J Young,A Fry-Smith,C Hyde - 《Thorax》 被引量: 128发表: 1999年 Economic analysis of lung volume reduction surgery as part of the nat...
Blood eosinophil count correlates with alveolar damage in emphysema-predominant COPD Article Open access 13 October 2024 Clinical and radiological characteristics of patients with late-onset severe restrictive lung defect after hematopoietic stem cell transplantation Article Open access 07 September 2017 ...
A striking finding, in particular in lungs of patients with severe COPD, often with a predominant emphysema phenotype, is the presence of B-cell follicles. As seen in other tissues, these follicles are the result of lymphoid neogenesis. The finding of oligoclonality in B-cell follicles in ...
In a proof-of-concept experiment, researchers from Johns Hopkins Medicine say they have successfully used microscopic man-made particles to predict the severity of patients' chronic obstructive pulmonary disease (COPD) by measuring how quickly the partic
Hypercapnia– increased level of CO2 in the blood, due tochronic obstrucive pulmonary disease (COPD – bronchitis or emphysema), sleep apnea, miastenia gravis,resulting in: recurrent severe both-sided headache, shortness of breath, sleepiness or delirium ...
There has been dramatic resurgence of interest in surgical treatment of emphysema, particularly "lung volume reduction" procedures. Recent studies have dem... M Brenner,R Yusen,McKenna, Robert,... - 《Chest》 被引量: 1970发表: 1996年 Global burden of COPD: systematic review and meta-analysis...
Decreasing cardiac chamber sizes and associated heart dysfunction in COPD: Role of hyperinflation 2010, Chest Show abstract Percent emphysema, airflow obstruction, and impaired left ventricular filling 2010, New England Journal of Medicine Show abstract Effects of hyperinflation on the oxygen pulse as a...
Aim: Alpha-1 antitrypsin deficiency is an autosomal co-dominant condition that predisposes individuals to early-onset emphysema. As with COPD, AATD-COPD is associated with pulmonary exacerbations, which impacts on overall mortality and quality of life. Though there is evidence t...