Asthma is the commonest chronic disease in children. Children and young people (CYP) with severe asthma represent only about 5% of this cohort but have a high burden of disease due to persistent asthma symptoms and/or regular asthma attacks that often require hospitalization. CYP with severe ...
Pediatr Phenotypes and endotypes of severe asthma in children Young Yoo, MD, PhD Department of Pediatrics, Allergy Immunology Center, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea Severe childhood asthma is a complicated and heterogeneous disorder with ...
In this review of severe asthma in children, the term problematic severe asthma is used to describe children with any combination of chronic symptoms, acute severe exacerbations and persistent airflow limitation despite the prescription of multiple therapies. The approach to problematic severe asthma ...
Severe asthma or therapy-resistant asthma in children is a heterogeneous disease that affects all age-groups. Given its heterogeneity, precision in diagnosis and treatment has become imperative, in order to achieve better outcomes. If one is thus able to identify specific patient phenotypes and endo...
Most children with asthma respond to low doses of inhaled corticosteroids, but a few remain symptomatic despite being prescribed the routine usual asthma medications. The first steps are to ensure that the diagnosis is correct and that the inhaled medications are being given regularly with an approp...
Most children with asthma respond to low doses of inhaled corticosteroids, but a few remain symptomatic despite being prescribed the routine usual asthma medications. Th e fi rst steps are to ensure that the diagnosis is correct and that the inhaled medications are being given regularly with an ...
Severe Asthma in Children and Adolescents Marina Martinez-Garri & Jonathan M. Gaffin 1458 Accesses Abstract The evaluation of pediatric patients with severe asthma requires assessment for underlying comorbidities that complicate asthma and make its treatment more difficult. Asthma in such patients has ...
Eleven children died during the study—only one of whom was certified as dying as a result of COVID-19—and none of the deaths were in children with asthma. "We looked at different markers of disease severity and although the group of children with asthma generally required a longer duration...
OBJECTIVE: The purpose of the study was to evaluate the dose-response relationships of the inhaled corticosteroid budesonide in a double blind crossover study in 19 children with moderate and severe asthma. METHODS: A 2-week placebo treatment period (run-in) was followed by three 4-week treatme...
In severe asthma lung function assessment is used to distinguish different phenotypes, children with severe asthma have worse airflow limitation prior to administration of a bronchodilator than children with non severe asthma. Airway resistance and reactance are indirect measurements of airway obstruction ...