Severe alcohol-associated hepatitis (SAH) is the most critical, acute, inflammatory phenotype within the alcohol-associated liver disease (ALD) spectrum, characterized by high 30- and 90-day mortality. Since several decades, corticosteroids (CS) are the only approved pharmacotherapy offering highly ...
DURECT has dosed the first patient in its AHFIRM randomized, double-blind, placebo-controlled, multi-center Phase 2b study to evaluate the safety and efficacy of DUR-928 in severe alcohol-associated hepatitis (AH) patients. "We are excited to have begun ...
Recent advances in alcohol-related liver disease (ALD): Summary of a Gut round table meeting 2020, Gut Meeting Report: The Dallas Consensus Conference on Liver Transplantation for Alcohol Associated Hepatitis 2020, Liver Transplantation Predicting Low Risk for Sustained Alcohol Use After Early Liver Tr...
An Open-Label, Dose-Escalation Study to Assess the Safety and Efficacy of IL-22 Agonist F-652 in Patients With Alcohol-associated Hepatitis 2020, Hepatology Recent advances in alcohol-related liver disease (ALD): Summary of a Gut round table meeting 2020, Gut Diagnosis and Treatment of Alcohol...
Background: The precision of clinical criteria and the utility of liver biopsy for diagnosis or prognosis remain unclear in patients with alcohol-associated hepatitis (AH). We systematically reviewed the literature to answer these questions. Methods: Four databases were searched for studies describing ...
The most effective treatment for alcoholic liver disease is abstinence from alcohol and it is the only treatment for patients with alcoholic fatty liver. Although many empirical therapeutic agents have been studied in the short-term and long-term treatment of alcoholic hepatitis, results have been ma...
Severe alcoholic hepatitis in Japan: prognosis and therapy. Background: Recently, the incidence of alcoholic liver disease (ALD) has been increasing in Japan; this associated with an increase in alcoholic beverage ... Y Horie,H Ishii,T Hibi - 《Alcoholism-clinical & Experimental Research》 被引...
2023 Waiting List Registration and Liver Transplant for Alcoholic Hepatitis During COVID-19 JAMA Network Open Research October 26, 2021 Diagnosis and Treatment of Alcohol-Associated Liver Disease JAMA Review July 13, 2021 Select Your Interests This Issue Views 30,211 Citations 148 78 Download PDF ...
Liver transplantation in acute alcoholic hepatitis:Current status and future development Acute alcoholic hepatitis (AH) is a distinct clinical entity amongst patients with chronic alcohol abuse.Patients with severe AH are at risk of dying in ab... Ashwani,K,Singal,... - 《World Journal of Hepatol...
Patients with severe alcoholic hepatitis (SAH) not responding to glucocorticoid therapy have higher mortality, though they do not differ in their baseline clinical characteristics and prognostic scores from those who respond to therapy. We hypothesized that the baseline hepatic gene expression differs betw...