Thus, strategies targeting common oligomeric conformation would be an appealing approach to circumvent oligomer-mediated cytotoxicity by various amyloids, such strategies are widely believed to be a more effici
In prediction modeling, neural networks are the most common AI type; Bayesian networks are used to represent probabilistic graphical models; and decision trees offer decision-support tools. In the meantime, a multivariate regression method is utilized to determine the correlation between the experimental...
The major limitations in cancer chemotherapy strategies are the low intracellular bioavailability of drugs, off-target toxicity, and the presence of multidrug resistance (MDR). A common reason why many anticancer molecules do not become viable drug leads is their poor ability to achieve site-specific...
Thus, strategies targeting common oligomeric conformation would be an appealing approach to circumvent oligomer-mediated cytotoxicity by various amyloids, such strategies are widely believed to be a more efficient treatment method for amyloidoses than agents targeting a single type of amyloid. Moreover, ...
At present, three strains of influenza viruses have led to human pandemics: H1N1, H2N2, and H3N2 [143,144]. Even though great efforts have been made to treat these infections, new antiviral drugs are needed due to the increasing resistance of the influenza viruses to current treatments [144...