Top-down mass spectrometry (MS)-based proteomics provides a comprehensive analysis of proteoforms to achieve a proteome-wide understanding of protein functions. However, the MS detection of low-abundance proteins from blood remains an unsolved challenge due to the extraordinary dynamic range of the blo...
MEANS AND METHODS FOR DETERMINING RISK OF TYPE-1 DIABETES BY SERUM PROTEIN BIOMARKERSThe present invention relates to methods for predicting a risk of a subject for Type 1 diabetes (T1D) on the basis of expression levels of protein markers in a sample obtained from the subject. The present ...
The overall protein composition of a patient's plasma or serum should be studied first in terms of its total protein content. The total protein concentration of serum in healthy adults is 60–80gl−1. There are two general causes of alterations ofserum total proteins: change in the volume ...
MEANS AND METHODS FOR DETERMINING RISK OF TYPE-1 DIABETES BY SERUM PROTEIN BIOMARKERSThe present invention relates to methods for predicting a risk of a subject for Type 1 diabetes (T1D) on the basis of expression levels of protein markers in a sample obtained from the subject. The present ...
We also treated neutrophils with LPS by 152 ng/ml (low dosage, as S100A12 recombinant protein) and 1 μg/ml (high dosage, as suggested by other studies), followed by the same assays shown in Fig. 6c. Compared with control set (no LPS treated), no significant variation of relative ...
Maternal mid-pregnancy C-reactive protein and risk of autism spectrum disorders: the early markers for autism study. Transl Psychiatry. 2016;6(4):e783. Article CAS PubMed PubMed Central Google Scholar Brown AS, Sourander A, Hinkka-Yli-Salomäki S, McKeague IW, Sundvall J, Surcel HM...
For pooled serum specimen, proteins were first separated into low and high abundant protein fractions in the supernatant and the precipitate by ACN precipitation. Proteins in the supernatant and the precipitate were processed with tryptic digestion and HILIC enrichment respectively to generate two N-lin...
Alpha-Klotho protein in systemic lupus erythematosus. Clin Exp Rheumatol. 2023;41(1):41–7. Ligumsky H, Merenbakh-Lamin K, Keren-Khadmy N, Wolf I, Rubinek T. The role of alpha-klotho in human cancer: molecular and clinical aspects. Oncogene. 2022;41(40):4487–97. Article CAS Pub...
concentrations of SELENOP and selenium at baseline in people with or without the development of glucose intolerance at follow up. We defined the onset of glucose intolerance by combining participants diagnosed with type 2 diabetes and those with impaired glucose tolerance. Data represent the means ...
With the growing number of genetic association studies, the genotype-phenotype atlas has become increasingly more complex, yet the functional consequences of most disease associated alleles is not understood. The measurement of protein level variation in