Serum protein electrophoresis (SPE) in combination with immunotyping (IMT) is the diagnostic standard for detecting monoclonal proteins (M-proteins). However, interpretation of SPE and IMT is weakly standardized, time consuming and investigator dependent. Here, we present five machine learning (ML) ...
Of the factors examined, the monoclonal protein level was significantly higher in patients with isolated prolonged PT and correlated with PT. 展开 关键词: Prothrombin time serum immunoglobulin plasma cell dyscrasia DOI: 10.1111/ijlh.12036 被引量: 15 ...
Patients with an initial diagnosis of MGUS should have a serum protein electrophoresis (SPEP) rechecked in 6 months. Risk stratification by free-light chain (FLC) ratio, immunoglobulin (Ig) type, and serum monoclonal(M) protein level is ... C.K. Jacobs - Evidence-Based Practice 被引量: ...
The role of bone marrow biopsy in patients with plasma cell disorders: should all patients with a monoclonal protein be biopsied? Article Introduction Serum-free light chains (FLC) are important biomarkers for the diagnosis and management of smoldering multiple myeloma (SMM), multiple myeloma (MM),...
Regarding the remaining EGFR-ligands, we found no associations between preoperative level of either S-EGF, S-BTC, S-AREG or S-TGFα and OS or IDFS in the entire study population. However, when performing subgroup analysis, results showed that S-AREG ≥ 5.3 pg/mL was associated with...
Production of Monoclonal Antibodies in Serum-free Media.###Preparation of Monoclonal Antibodies Against Bovine Progesterone.###Preparation and Characterization of a Monoclonal Antibody Against Morphine.###Isolation and Characterization of Monoclonal Antibodies Against a Virion Core Protein of Orf Virus Strain...
Human serum mannose binding protein (MBP): Development of an enzyme-linked immunosorbent assay (ELISA) and determination of levels in serum from 1085 normal... ITKF Hagiwara - 《Biochemical Medicine & Metabolic Biology》 被引量: 129发表: 1993年 Development of an enzyme-linked immunosorbent assay...
[15]. Furthermore, it has been shown that this assay may also cross-react with proteins that have a similar structure to sclerostin, which was evidenced by the detection of low “sclerostin” protein levels in the serum of sclerosteosis patients (i.e., patients in which functional or ...
Serumprotein electrophoresis(SPEP) is an inexpensive, easy-to-perform screening procedure for initial identification of monoclonal bands. Monoclonal bands are usually seen in the gamma zone, but may be seen in proximity to the beta band or rarely in the alpha-2 region. Blood can be collected in...
Protein–protein interactions among the positional candidate genes at the GWAS loci were predicted using InWeb_InBioMap84, a curated and computationally derived regulatory network of 420,000 interactions (Supplementary Fig. 6). We used high confidence interactions defined by the recommended cut off con...