In the survival group, the lactate clearance rate measured over the course of 1week post-admission was significantly higher than that measured for the death group. The area under the curve (AUC) for predicting the prognosis of HBV-related ACLF patients in short-term (within 3-month) with a...
These results agree well with a recent study showing significant increases in urinary levels of metabolites, including hippuric acid, succinic acid, lactic acid, taurine, creatine, and TMAO, in 18 FM patients (vs 20 healthy controls)54. As well, an algorithm consisting of succinic acid, ta...
Other small molecule nutrients found in high abun- dance in serum include amino acids (10 mM–1155 mM), glucose, glycerol, lactate, oxygen, carbon dioxide (in the form of bicarbonate ions) and several waste or catabolic byproducts such as urea and creatinine. A more detailed description of ...
In acute myeloid leukemia patients [32], serum uric acid has been shown to be an independent predictor of AKI and tumor lysis syndrome with superior predictive performance than conventional markers such as lactate dehydrogenase, cytogenetic profile and tumor markers. In order to confirm the ...
This is in agreement with a previous study that demonstrated an approximately 50% of the study subjects with HHS had an increased anion gap metabolic acidosis as a result of a concomitant ketoacidosis and/or an increase in serum lactate levels [30]. Studies on serum osmolality and mental ...
induces changes in the microbiota, as some of the bacteria detected in this study includingRomboutsia, RuminococcusandClostridiumexhibit urease activity37,38. In fact, a recent study demonstrated that the lactate produced during exercise can increase the abundance of theVeillonellagenus in gut microbiota...
Among the pathways related to the fermentation to SCFAs, heterolactic fermentation (MetaCyc pathway: P122-PWY), and Bifidobacterium shunt (P124-PWY) were decreased, whereas hexitol fermentation to lactate, formate, ethanol, and acetate (P461-PWY) was increased in high vs. low fecal calprotectin...
Its quite well know that high levels of serum lactic acid correlates with poor general condition and poor surgical outcome. Postoperative elevated serum lactate during the first 24h is associated with morbidity and even mortality in patients undergoing elective abdominal surgeries. In this study we ...
Similarly, a rise in interstitial lactate has also been observed in the brain injury of rats32,34. In this work, we have shown that an elevated level of CSF lactate is also present in human patients, and the response is related to injury severity. This is also consistent with our ...
15 metabolites were identified intimately associated with the process. Phenylalanine, malic acid and 5-methoxytryptamine for HBVvs. NC, palmitic acid for LCvs. HBV and asparagine and β-glutamate for HCCvs. LC were screened as the liver disease-specific potential biomarkers with an excellent discrim...