Axiak SM, Krishnamoorthy L, Guinan J, et al. Quantitation of free kappa light chains in serum and urine using a monoclonal antibody based inhibition enzyme-linked immunoassay. J Immunol Methods. 1987;99:141-147.Axiak SM et al. " Quantitation of free kappa light chains in serum and urine ...
and two identical light chains (kappa –κ or lambda –λ). Immunoglobulin heavy and light chains each have constant and variable regions. A pair of heavy and light chain variable regions together forms the antigen-binding site. The variable regions exhibit enormous structural diversity, ...
The concentration of normal human serum kappa light chain is about two times of that of lambda light chain. The serum total light chain (sTLC) includes the light chain bound to a heavy chain as part of an intact immunoglobulin and the free light chain in serum (serum free light chain (...
In healthy individuals, plasma cells originating from the bone marrow produce immunoglobulin molecules composed of two heavy chains and two light chains. There are two types of light chains in humans, kappa and lambda. The chapter provides an overview of
The polyclonal serum free light chain assays (sFLC) identify epitopes on the Kappa (K) or Lambda (L) light chain component of the immunoglobulin that are only exposed when not bound to its heavy chain partner. Since 2006 the assays have been included in International guidelines for detection ...
N latex FLC - new monoclonal high-performance assays for the determination of free light chain kappa and lambda. Clin Chem Lab Med. 2011;49(8):1323–32. Article PubMed CAS Google Scholar Campbell JP, Cobbold M, Wang Y, Goodall M, Bonney SL, Chamba A, Birtwistle J, Plant T, Afzal...
Samples were assessed for total IgG, total IgA and total IgM (Dade Behring, Siemens, Germany), serum free kappa (FLCk) and serum free lambda (FLCl) light chains (Freelite, The Binding Site Group Ltd, Birmingham, UK) and cystatin C (The Binding Site Group Ltd). The reference range used...
The paper deals with examination of free kappa light chains (FKLC) in the cerebrospinal fluid and serum of patients with multiple sclerosis (MS). The patient group included 84 women (mean age 34.03 ± 10.33 years) and 24 men (mean age 33.81 ± 10.61 years). The average disease duration ...
Role of nephelometry-based detection of serum free light chain kappa/lambda in diagnosis of multiple myelomaZarabpouri, FPopov, JMontana, LFerruzza, A SNaides, S J
Kappa Free Light Chain Drift Prompts the Need for a New Upper Limit of Normal Free Light Chain Ratio to Avoid an Epidemic of Kappa Light Chain Monoclonal Gammopathy of Undermined Significance 2023, Journal of Applied Laboratory Medicine In response to: Defining new reference intervals for serum fre...