SERTOLI cellsSPERMATOGENESISINHIBINFOLLICLE-stimulating hormoneFocuses on the changes in Sertoli cell function and spermatogenesis in ageing. Demonstration that inhibin B is the relevant dimeric form of inhibin in men; Increase in inhibin B concentration during puberty; Changes in the relation...
Here, we provide an overview of the effects on follicle-stimulating hormone (FSH), insulin-like growth factor (IGF) system, androgen, and estrogen signaling pathways on Sertoli cells (SC) function and the “niche” microenvironment, and an overview of molecular interference associated with obesity ...
Thanks to the development of a procedure enabling the obtainment of pure cultures of mature Sertoli cells studies on the effects of hormones and on the ability of Sertoli cells to elaborate substances with possible biological function were undertaken and reviewed. The 1st study attempted to elucidate...
human Sertoli cellslactateestradiol-17βtransferrinprimary culturesHuman Sertoli cell parameters, namely lactate, estradiol-17, and transferrin production, were determined after a 24-hour incubation with either human follicle stimulating hormone (FSH) or dbcAMP in the presence or absence of testosterone ...
6. A Highlights from MBoC Selection: Nesprin-3 connects plectin and vimentin to the nuclear envelope of Sertoli cells but is not required for Sertoli cell function in spermatogenesis [O] . Mirjam Ketema, Maaike Kreft, Pablo Secades, 2013 机译:MBoC选择的亮点:Nesprin-3将Plectin和波形蛋白...
Evidence shows that peritubular cells also play an important role in regulation of the testis, responding to testosterone from the Leydig cells and modulating Sertoli cell function (e.g., production of androgen-binding protein). Leydig Cells Interstitial tissue between the seminiferous tubules is ...
Sertoli cells are a highly specialized cells found in the testes. They played an important role in the development and maturation of sperm cells, or spermatozoa, within the testes, a process called spermatogenesis. Because Sertoli cells function largely to assist the developing sperm cells through...
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Sertoli cells, the fertility of mutant mouse was impaired with smaller testis size and decreased sperm production at adult64. The various trends ofSmadexpression and deleted phenotype demonstrate that the TGF-β/Smad signaling pathway occupies a continuous crucial position for SCs function during ...
In addition, Sertoli cells produce anti-Müllerian hormone, resulting in the degeneration of the Müllerian duct. Postnatally, their main role is to support and nurture the development of sperm through the stages of spermatogenesis and also function in the production of androgen-binding protein and ...