The blood-testis barrier (BTB) is formed adjacent to the seminiferous basement membrane. It is a distinct ultrastructure, partitioning testicular seminiferous epithelium into apical (adluminal) and basal compartments. It plays a vital role in developing and maturing spermatocytes into spermatozoa via ...
此外,Sertoli细胞之间的紧密连接参与构成血-睾屏障(blood-testis barrier)。在生精小管与血液之间存在血-睾屏障,阻止血液中某些物质接触生精上皮,并且严格阻止精母细胞、精子与免疫系统接触,防止自身免疫应答反应。血-睾屏障维持了睾丸生精微环境的稳定。在生精小管之间富含血管和淋巴管的疏松结缔组织为睾丸间质,其中...
The blood-testis barrier is a structural and physiologic compartment created by inter–Sertoli celltight junctions located above the basally positioned spermatogonia and the earliest germ cells that develop from them, the leptotene/zygotene primary spermatocytes (Fig. 136-13and seen inFig. 136-2)....
百度试题 题目 the sertoli cells have the following functions: 相关知识点: 试题来源: 解析 supportingnourish germinal cellssecret angrogen- binding proteinconsititute the blood -testis barrierphagocytosis residual bodies 反馈 收藏
The Sertoli cells form the inner perimeter of the cross-sectioned seminiferous tubule, with the germ cell epithelium being the only other exterior cellular structures, resulting in mature spermatogonia and spermatids being interior to the Sertoli cell blood-testes-barrier.[8][9] Function Sertoli ...
(feisun@ustc.edu. cn) Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells Huijuan Zhang1, Yimeng Yin1, Guishuan Wang1, Zhimin Liu1, Lin Liu2 & Fei Sun1,2 1Department of Cell and Developmental Biology, School of ...
There is little information on the mitogenic and immunoregulatory activities of proteins, secreted by prepubertal Sertoli cells during the stage of meiosis initiation and before creation of the blood-testis barrier. We have previously demonstrated dose-dependent and age-related stimulation of BALB/c 3T3...
Key words: Sertoli cell; blood-testis barrier;Rab13; PKA 0 引言 哺乳动物血睾屏障(blood testis barrier, BTB) 将生精上皮分隔为基底小室与近腔小室 两部分, 为减数分裂Ⅰ /Ⅱ 期及减数分裂后期的精子细胞发育提供了相对独立的环境, 作为 “免疫屏障”, 在很大程度上避免了抗精子抗体的产生[1,2]。
Confirmed reports of ZIKV in human seminal fluid for months after the clearance of viremia suggest the ability of ZIKV to establish persistent infection in the seminiferous tubules, an immune privileged site in the testis protected by the blood-testis barrier, also called the Sertoli cell barrier ...
At ~80% confluency, they were used for studies including toxicant exposure, immunoblotting, immunofluorescence analysis, tight junction (TJ)-permeability assessment, and overexpression of BTB (blood-testis barrier) regulatory genes such as FAK and its phosphomimetic mutants. PFOSwas found to induce ...