Silverman, SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases, J. Biol. Chem. 276 (2001) 49320 - 49330.Askew YS, Pak SC, Luke CJ, Askew DJ, Cataltepe S, Mills DR, Kato H, Lehoczky J, Dewar K, Birren B...
, 2013). Serpins are classified in family I4 of the MEROPS database; two major divisions of the serpins are the extracellular and intracellular groups (clades A and B, respectively). The inhibitory serpins inactivate their target proteases through an unusual ‘suicide’ mechanism that exploits ...
中文名称:Anti-SERPINB2 Polyclonal Antibody英文名称:Anti-SERPINB2 Polyclonal Antibody Subcellular Locations:Cytoplasm Cytoplasm SecretedSwiss Prot:P05120 保存:Store at -20°C. Avoid freeze / thaw cycles.别名:HsT1201;PAI;PAI-2;PAI2;PLANH2;serpin family B member 2 ...
SERPINB9 belongs to the family of serine protease inhibitors, implicated in diverse physiological processes [19]. Previous research indicates that SERPINB9 is markedly expressed in tertiary tumorspheres, which are also characterized by elevated levels of stem cell markers [41]. It has been posited...
pylori, normal fibroblasts, and GC cells induced the activation of fibroblast into CAFs and upregulation of Serpin family E member 1 (Serpin E1) by GC cells, thereby promoting gastric carcinogenesis. However, it remains unclear whether Serpin E1 is produced by fibroblasts or cancer cells in the...
In addition, it displays all of the structural features unique to the ovalbumin family of serpins (ov-serpins). The amino acid sequence of the hinge region in the reactive site loop suggests that hurpin has the potential for protease inhibition. The putative reactive center P-Presidues were ...
By using the two long-term estrogen deprivation (LTED) derivatives generating from MCF-7 and T47D, we found that the downregulation of serine protease inhibitor serpin family A member 3 (SERPINA3), a member of the serine-protease inhibitor family, could induce endocrine-resistance through ...
(USRs) identified by IPA where USRs associated with NF-κb (Fig.S1b). Consistent with these findings, significantly higher levels of DNA binding by NF-κb family members was seen in nuclear extracts from SerpinB2+/+RPM than in nuclear extracts from SerpinB2−/−RPM (Fig.S1c). ...
Granzyme B: pro-apoptotic, antiviral and antitumor functions Granzyme B is a caspase-like serine protease that is released by cytotoxic lymphocytes to kill virus-infected and tumor cells. Major recent advances in our... Joseph,A,Trapani,... - 《Current Opinion in Immunology》 被引量: 320发表...
[22]. For the human gene, the mouse serine protease inhibitor A3 family exists in 14 gene clusters located on chromosome 12F1 (named serine protease inhibitors A3a-n) [21], which has 70% homology with human genes [23]. Therefore, it is considered the functional ortholog of human SerpinA...