This chapter discusses how 5-hydroxytryptamine (5-HT) appears to be accumulated by a specific uptake system in 5-HT nerve terminals and presents a system that involves a kinetic analysis of the affinity for potential transmitters for transport into nerve terminals in the brain. Biogenic amines ...
High affinity [3H]imipramine binding sites in mammalian brain have been described to be related to the serotonin transporters. Several antidepressants have been labeled to investigate serotonin transporters in living human brain by positron emission tomography (PET). Cyanoimipramine which is described as...
A new thesis from he Swedish medical university Karolinska Institutet shows that the brain’s serotonin system differs between men and women. The scientists who conducted the study think that they have found one of the reasons why depression and chronic anxiety are more common in women than in m...
The serotonergic system in the brain modulates many types of behavioural and physiological processes. An example of this modulatory function is seen with the selective serotonin reuptake inhibitors (SSRIs) which enhance serotonin transmission and influence mood, anxiety states, aggression, feeding and sex...
Properties involved in the maintenance of the steady‐state level of serotonin were studied in the brains of mice showing a genetically determined susceptibility or resistance to audiogenic seizures. Animals susceptible to sezures appear to possess an inefficient 5‐HT system which stimulates a compensa...
After training in a defensive situation, increased activity of the noradrenergic system was observed. The character of the change in the brain biogenic amine level during training thus depends on the emotional quality of the reinforcement used....
Serotonin (5-hydroxytryptamine or 5-HT) is synthesized from the amino acid tryptophan. It is a major neurotransmitter, considered an indolamine monoamine, that is particularly important in central nervous system modulation, especially in the brain. Serotonin is also found in peripheral sites and rega...
These data suggest that the adminis- tration of exogenous cannabinoids leads to sustained upregulation in the brain's endogenous endocannabinoid (eCB) system that is associated with behavioral sequelae. Discussion: These data show that cannabinoid administration leads to long term molecular and behavioral...
The anatomical distribution of serotonin-2 receptors in the human brain was studied by light microscopic autoradiography, using [ 3H]ketanserin as a ligand. The receptor densities were quantified by microdensitometry with the aid of a computer-assisted image-analysis system. A heterogeneous distribution...
Neuropsychiatric disorders have long been linked to both immune system activation and alterations in serotonin (5-HT) signaling. In the CNS, the contributions of 5-HT modulate a broad range of targets, most notably, hypothalamic, limbic and cortical circuits linked to the control of mood and moo...