Serotonin syndromeTramadolSetting: University-based outpatient clinic. Participant: A 57-year-old woman with chronic low back pain (CLBP) due to lumbar radiculopathy. Case Description: The patient, who had a me
medication, a change in dose, addition of a new drug, or overdose attempt. Death may occur as a consequence ofrhabdomyolysiswith renal failure,hyperkalemia,disseminated intravascular coagulation, and acute respiratory distress syndrome. The differential diagnosis includesneuroleptic malignant syndrome, viral...
contrast to neuroleptic malignant syndrome, the onset of serotonin syndrome is usually rapid; (3) hyperthermia is a hallmark of severe serotonin syndrome; and (4) serotonin syndrome can readily be distinguished from neuroleptic malignant syndrome on clinical grounds and on the basis of medication ...
Serotoninsyndrome(SS)orserotonintoxicityconsistsofthetriadofalteredmentalstatus(confusion,agitation,seizures),dysautonomia(diarrhea,diaphoresis,hypertension,fever/shivering,mydriasis,tachycardia),andneuromuscularchanges(myoclonus,tremor,ataxia,hyperreflexia,rigidity).Thereare2validatedsetsofcriteriafordiagnosingSS.Thefirst...
In 2006, the US Food and Drug Administration (FDA) issued an advisory about the risk of serotonin syndrome associated with concomitant use of drugs from 2 widely prescribed medication classes: (1) selective serotonin reuptake inhibitor (SSRI) and selective norepinephrine reuptake inhibitor (SNRI) ...
Selective serotonin reuptake inhibitors in pregnant women and neonatal withdrawal syndrome: a database analysis. Lancet 365: 482–487. Spielberger CD, Gorsuch I, Lushene RE (1970). Manual for the State-Trait Anxiety Inventory. Consulting Psychologists Press: Palo Alto, CA. ten Hof J, Nijhuis ...
Treatment consists primarily of discontinuing the offending medication, which results in the rapid resolution of symptoms. Resolution may be more gradual with medications such as fluoxetine, due to their long half-life. Supportive care is the mainstay, and mild cases of serotonin syndrome can be ma...
The serotonin syndrome (SS) is a potentially life-threatening disorder in humans which is induced by ingestion of an overdose or by combination of two or more serotonin (5-HT)-enhancing drugs. In animals, acute administration of direct and indirect 5-HT agonists also leads to a set of behav...
As clinicians become more aware of serotonin syndrome, and as drug combinations become more common, it is possible we will see more cases of toxic interactions involving trazodone combinations in the literature. Nefazodone–SSRI interactions have not been well described in the literature. There are...
F10-F19: Mental and behavioural disorders due to psychoactive substance use include, for example, delirium tremens, psychotic disorder, and amnestic syndrome, due to various substance use. F20-F29: Schizophrenia, schizotypal disorders, and delusional disorders include, for example, paranoid schizophrenia...