5-httlpr polymorphismassociation studyThe available data from preclinical and pharmacological studies on the role of the serotonin transporter (5-HTT) support the hypothesis that a dysfunction in brain serotonergic system activity contributes to the vulnerability to affective disorders (AD). 5-HTT is ...
Polymorphism of the 5-HTTLPR serotonin transporter gene is one of the best studied markers of the serotoninergic system. Scientific interest in investigating 5-HTTLPR polymorphism arises because many studies have demonstrated an association between the short allele (S) and the development of a number ...
Incorrect Wording: In the Review article titled "Interaction Between the Serotonin Transporter Gene ( 5-HTTLPR ), Stressful Life Events, and Risk of Depression: A Meta-analysis" by Risch et al, published in the June 17, 2009, issue of JAMA (2009;301[23]:2462-2471), incorrect wording ...
The etiology of late-onset Alzheimer’s disease (AD) and idiopathic Parkinson’s disease (PD) is not known. In both disorders there is an extensive degeneration of serotonergic neurons, with corresponding losses of the serotonin (5HT) transporter (5HTT), which is responsible for the reuptake of...
Understanding the common dimension of mental disorders (such as anxiety, depression, and drug addiction) might contribute to the construction of biological frameworks (Research Domain Criteria, RDoC) for novel ways of treatment. One common dimension at t
The innovative study design elaborates that androgen receptor trinucleotide repeats and 5‐ HTTLPR genotypes have combinatorial impact on hormonal milieu and sexual function regarding evidence‐based lifelong premature ejaculatory dysfunction patients. 展开 ...
Serotonin (5-hydroxytryptamine, 5-HT) signaling is involved in neurodevelopment, mood regulation, energy metabolism, and other physiological processes. DNA methylation plays a significant role in modulating the expression of genes responsible for maintai
View LargeDownload Mean ± SD serotonin transporter (5-HTT) binding in Brodmann areas in the prefrontal cortex subdivided by sulcus (S) and gyrus (G): comparison of 5-HTTLPR genotypes. SS indicates short form of the 5-HTTLPR locus in the homozygote (n = 33); SL, short and long form ...
Using genetic analysis, the researchers identified genetic variants in the SERT gene region 5-HTTLPR that affect SERT activity. They found that a “long” variant of 5-HTTLPR makes SERT less active in the mitral valve cells, especially when there are two copies (one maternal and one ...
POD-09.01: Analysis of Association Between the 5-HTTLPR and Stin2 Polymorphisms in the Serotonin Transporter Gene and Clinical Response to Selective Serotonin Reuptake Inhibitor (Sertraline) in Patients with Premature Ejaculation Urology, Volume 74, Issue 4, Supplement, October 2009, Pages S27 PDF (...