2003. Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia. Am J Med Genet Part B 121B(1):7-13.Suzuki T, Iwata N, Kitamura Y, Kitajima T, Yamanouchi Y, Ikeda M, Nis
yet the underlying molecular machinery remains poorly understood. Here, we employ high-resolution time-lapse FRET imaging in neuroblastoma cells and neuronal dendrites to establish that activation of serotonin receptor 5-HT4(5-HT4R)
Antidepressants with a Rapid Onset of Action by Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G. Université McGill, Département de Psychiatrie, Bâtiment de Recherche et de Formation, Bureau ...
多巴胺和5-羟色胺PCR芯片可用于研究与多巴胺和5-羟色胺系统有关的84个关键基因的表达。多巴胺和血清素是哺乳动物的神经系统的主要神经递质系统。多巴胺影响大脑过程,控制运动和情感行为,并在大脑的奖励机制发挥重要作用。5-羟色胺是温度调节、感官知觉、运动、睡眠和精神病的关键。针对多巴胺/血清素激活的神经传递的药...
In vitro and mouse studies identified a dual serotonin (5-HT4) receptor partial agonist and AChE inhibitor that could help treat AD.
In particular, compound 1C [SC-52491], an azanoradamantane, exhibits an EC50 of 51 nM in a functional model of 5-HT4 agonism and potent antagonism, Ki = 1.2 nM, at the 5-HT3 receptor.Access through your organization Check access to the full text by signing in through your organization...
靶点 5-HT Receptor 动物实验 通过在饮用水中口服施用5%DSS 5天诱导葡聚糖硫酸钠 (DSS) 结肠炎。在另一个实验中, IL-13 – / – 小鼠皮下注射100mg / kg盐酸5-羟色胺 (5-HTP) , 每天两次, 在诱导DSS结肠炎前3天开始, 持续8天; 而对照IL-13 – / – 小鼠接受盐水作为载体。在每次实验结束时通过...
Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse. 机译:5-HT(4)受体基因敲除小鼠中缝核的5-羟色胺神经元的适应性变化。 获取原文 获取原文并翻译 | 示例 获取外文期刊封面封底 >> 开具论文收录证明 >> 文献代查 >> 页面...
Anti-emetic effect of mosapride citrate hydrate, a 5-HT4 receptor agonist, on selective serotonin reuptake inhibitors (SSRIs)-induced emesis in experimental animals. J Pharmacol Sci 121: 58-66.Mine Y,Oku S,Yoshida N.Anti-emetic effect of mosapride citrate hydrate a5...
Since its discovery in mouse colliculi neuronal cells and in the guinea pig ileum, the 5-HT4 receptor (5-HT4R) has stimulated a great deal of interest [3], [4], and has been taken into consideration as a promising target for drug design. 5-HT4Rs are especially expressed in the ...