[2]. The majority of these enzymes fall into the large alpha/betahydrolase(ABH) fold superfamily, first classified in 1992 [3]. Thisprotein superfamilyis found in all domains of life serving catalytic roles in primary and specialized (secondary) metabolism asesterases, thioesterases,lipases,...
Design and synthesis of quenched activity-based probes for diacylglycerol lipase and α,β-hydrolase domain containing protein 6 Chem. Asian J., 13 (2018), pp. 3491-3500 CrossrefView in ScopusGoogle Scholar Vosyka et al., 2013 O. Vosyka, K.R. Vinothkumar, E.V. Wolf, A.J. Brouwer,...
The hydrolase activity (GO: 0016787) is the major molecular function of the identified SHs. Full size image Cupin domain-containing storage protein Os12Ssp encodes protease activity In addition to the well-known group of SHs, we also identified 31 uncharacterized proteins (56%) that belong to ...
Synthesis of Serine Hydrolase Inhibitor ABL303 ABL303 is an aza-β-lactam that selectively inhibits serine hydrolases such as the α, β-hydrolase domain containing 10 and protein phosphatase methyleste... P. Kocieński - 《Synfacts》 被引量: 0发表: 2012年 ...
we have tested this hypothesis by screening ABLs more broadly against cell and tissue proteomes by competitive activity-based protein profiling (ABPP), leading to the discovery of lead inhibitors for several serine hydrolases, including the uncharacterized enzyme α,β-hydrolase domain-containing 10 (...
Coding sequences of 11 of the 21 serine hydrolases have been interrupted by transposon insertions without lethal consequences (Table 1); in all but one of these sequences, the insertion sites were in or N-terminal to the serine hydrolase domain, which strongly suggests that the catalytic ...
I.e., drebrin-like protein. A.k.a. 55-kDa HPK1-interacting protein (HIP55), SH3 domain-containing protein SH3P7, and filamentous actin-binding protein ABP1. It activates HPK1 and JNK during TCR signaling, particularly regulating the JNK1 cascade [274,275]. ...
et al. A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Nat. Struct. Mol. Biol. 20, 508–514 (2013). Article CAS PubMed Google Scholar Sharifi, R. et al. Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. EMBO J...
英文名称: [Wnt protein] O-palmitoleoyl-L-serine hydrolase 英文同义词: [Wnt protein] O-palmitoleoyl-L-serine hydrolase CAS号: 分子式: 分子量: 0 EINECS号: Mol文件: Mol File [Wnt protein] O-palmitoleoyl-L-serine hydrolase 信息错误报告 提交 按省份浏览[Wnt protein] O-palmitoleoyl-...
Evidence suggests that inhibition of α/β hydrolase-domain containing 6 (ABHD6) reduces seizures; however, the molecular mechanism of this therapeutic response remains unknown. We discovered that heterozygous expression of Abhd6 (Abhd6+/−) significantly reduced the premature lethality of Scn1a+...