The base compositions present clearly the A-T skew, which is most obvious in the control region and protein-coding genes. The extended termination-associated sequence domain, the central conserved domain, and the conserved sequence block domain are defined in the mitochondrial gen- ome control ...
A project aimed at discovering rare sequence variants with minor allele frequencies of 1% in normal genomes derived from HapMap samples. The Exome Project A project aimed at developing and validating cost-effective, high-throughput technologies for resequencing all of the protein-coding regions of th...
transcriptional state of a given cell, whereas more cells can provide us with a broader view of the biological variability in the cell population. A natural experimental design question arises (Fig.1a): how many cells should we choose to profile for a given study, and at what sequencing ...
Kcnj9 is represented with the coding region shown in the gray boxes and the 5' and 3' untranslated regions (UTRs) in the white boxes. Introns are illustrated as V-lines, and upstream region as a horizontal black line. The blue lines indicate SNPs found in MPD that we confirmed by ...
However, rs286 was in LD with a coding SNP, rs328 (Ser447×) (r2 = 0.81) that showed a modest association with HDL-C (P = 0.032) and a trend for association with TG (P = 0.088), as well as with three other SNPs (rs117026536, rs11570891 and rs1059611) that showed nominal ...
To attempt to locate mutations located at the 3′ end of HIV pot, primers were designed and tested to amplify a 2.1 kb region containing the entire coding region of protease and reverse transcriptase enzymes from HIV. pol. This assay will be used to amplify and sequence the AIDS Clinical ...
MicroRNAs (miRNAs) are small non-coding RNA molecules that play critical roles in post-transcriptional gene expression regulation. The aim of this study was to identify differentially expressed miRNAs in decidua and villus of recurrent miscarriage (RM) patients. Participants were recruited at the ...
Of these genes, 31 were tRNA coding genes, of which seven were located in the IR. A comparison with the F. vesca chloroplast genome sequence, the closest relative to P. micrantha for which a fully-sequenced chloroplast genome is available, revealed that the gene number and order within the...
Among them, a MADS-box gene (arahy.ATH5WE) was chosen as a candidate, as (1) it was the only one displaying a mutation within the coding sequence (a frameshift caused by a 1,870 bp deletion), and (2) the MADS-box family of transcription factors was previously associated with the...
Rare coding variation in PON1, likely to alter function and be deleterious, is associated with ischemic stroke risk (permutation P value = 3.01 × 10−3). Moreover, the association between this coding variation in PON1 and stroke is independent of the common functional PON1 variants, PON1...