AI helps researchers find meaning in molecules. (artificial intelligence used in gene sequencing) (Computing in Science) (Cover Story)Freedman, David
· The NovaSeq™ 6000 sequencing platform is by far Illumina’s most powerful sequencing platform. The improved chemical method and computing architecture breaks through the conventional upper limits of sequencing throughput. It was launched in the Chinese market in 2017, at the same time as the ...
sequencing reads retained in count matrices. Asterisk among technology names indicates mtscATAC-seq samples performed on PBMC that were viability FAC-sorted prior to tagmentation.f–h, Distributions of unique fragments in peaks (f), TSS enrichment (g) and fraction of unique fragments in peaks (h)...
minimum depth to consider a marker present in an individual is set to 5, meaning that markers with depth lower than 5 in an individual will not be considered present in this individual. Groups of individuals to compare (as defined in the popmap) are specified manually with the parameter--...
Preliminary data from the MAIS cohort have been discussed with the Indigenous leaders and volunteer individuals included in the study, explaining the meaning of the findings on health or population’s history, and the potential use of the data in future collaborations....
Meaning These findings suggest that clinical rtGS can be implemented in the neonatal acute care setting in a national public health care system. Abstract Importance National implementation of rapid trio genome sequencing (rtGS) in a clinical acute setting is essential to ensure advanced...
Meaning Analysis of longitudinal data from circulating tumor DNA may have implications for postoperative management of colorectal cancer that includes guiding adjuvant chemotherapy patient selection, guiding adjuvant chemotherapy duration optimization, and enabling earlier detection of clinical relapse. Abstract Im...
where the "extreme" values ofa'are from the setE(a,M):={a′:PrH0(a′|M)≤PrH0(a|M)}. If the p-value is sufficiently low, we reject the null hypothesis, meaning we assume that the two rows were not sampled from the same distribution. The quantity - log10(p-value(a|M))can ...
they are also useful for technology development runs and to optimize reaction conditions for a larger run. These machines have been referred to as 'personal sequencers', meaning that they are easily obtainable also by laboratories with smaller resources that want to have rapid access to a sequenc...
coding genes as well as many of the gene-expression regulatory elements. However there was much uninvestigated material dispersed between genes, the then called “junk DNA” and, up to 2003 not much was known about the function of this ‘junk DNA’. In addition there were two other problems...