they are also tolerated in normal skin and suggest that other events are required for transformation; it is not yet clear whether epigenetic regulators cooperate in the pathogenesis of cSCC. KDM6A encodes a histone H3K27me2/me3 demethylase that is frequently mutated in cSCC and other cancers. ...
We found significant correlations between tumour type and IASLC grade for ATM (P=0.022; P=0.008) and TP53 mutated patients (P>0.001; P<0.001). In addition, TP53 showed significant more multiple mutations (P<0.001). Both genes were also associated with lymph node invasion and distant metastasi...
The most common type is epithelial OC, a heterogenous cancer with five major histologically distinct subtypes: high-grade serous, low-grade serous, endometrioid, clear cell, and mucinous [1]. Due to the lack of any specific symptoms in early stages, most cases of OC are diagnosed at an ...