Sequential nab-paclitaxel/gemcitabine followed by modified FOLFOX for first-line metastatic pancreatic cancer: The SEQUENCE trial.613-135-244-3829,2,219,219,1700,54,239,193,176,7,3,3,3,2,2,2Background: Sequential treatment with nab-paclitaxel, gemcitabine followed by oxaliplatin, leucovorin and...
KRAS2 mutations in human pancreatic acinar–ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. Mol. Cancer Res. 7, 230–236 (2009). Article CAS PubMed PubMed Central Google Scholar Lo, H. G. et al. A single ...
KRAS2 mutations in human pancreatic acinar–ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. Mol. Cancer Res. 7, 230–236 (2009). Article CAS PubMed PubMed Central Google Scholar Lo, H. G. et al. A single ...
A multicenter clinical trial showed responses of multiple advanced tumors, including ovarian, breast, pancreatic, and prostate cancers, to poly(adenosine diphosphate-ribose) polymerase inhibitors, which led to the FDA approval of olaparib for treatment of women with BRCA-related advanced ovarian cancer ...
Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial. Lancet. 2016;387(10018):545–57. Article CAS PubMed Google Scholar Wainberg ZA, Melisi D, Macarulla...
(Wilcoxon-rank test,p-value = 3.93E−06); and pancreatic cancer (Wilcoxon-rank test,p-value = 1.192E−10). PDX tumors had even higher levels of murine viral loads than NSG and wild-type mice—a finding consistent with the previously reported lack of robust anti-infection ...
Duell EJ, Bracci PM, Moore JH, Burk RD, Kelsey KT, Holly EA: Detecting pathway-based gene-gene and gene-environment interactions in pancreatic cancer. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of...
An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res American Association for Cancer Research. 2006;12:4652–61. 5. DeRose YS, Wang G, Lin Y-C, Bernard PS, Buys SS, Ebbert MTW, et al. Tumor grafts derived from women with breast cancer authentically...
Trial Registration This trial is registered on Clinical Trials (Registration Number: NCT05694117) Funding The Fundamental Research Funds for the Central Universities: Number 135222026. CRediT authorship contribution statement Shichun He: Writing – review & editing, Writing – original draft. Meiqi Wei:...
Pax-4 is known to be a major regulator of pancreatic cell development and differentiation, and its transactivation domain was localized within its C-terminal region [41]. OCT-1 (Pou2f1) is well known as a widely expressed TRFs in most cells and tissues. Recently, a series of studies have...