Mutagenesis is a multi-step process starting with either replication error or DNA damage coupled with imperfect DNA repair and then manifests through replication as mutations in descendent cells [8,9]. Lesions are frequently formed from endogenous processes, such as the spontaneous deamination of cyto...
DNA sequences can be categorized into three groups according to their recurrence frequency16, as shown in Fig.1(a). The first group is composed of high-frequency repeats, also known as satellite DNA sequences (satDNAs), which are found in various regions of the chromosomes, including pericent...
Although the details of RNA replication and virus release are different for other viruses, this scheme is representative of the steps required for gene expression and RNA replication. Sign in to download full-size image FIGURE 1.10. Replication of an enveloped, plus-strand RNA virus. After the ...
of them involve a cascade of enzymatic preparation steps such as fragmentation, repair, ligation, cleavage or digestion. Lesions caused by UV radiation or reactive chemicals such as cisplatin, were successfully excised from the genomic DNA in a region around the damage and identified using specific...
The GoM DE analysis is part of a topic-model-based pipeline for analysis of single-cell RNA-seq [47] or ATAC-seq data [49]. This pipeline includes the following steps: (1) fit a topic model to the data; (2) visualize the structure inferred by the topic model; (3) run the GoM ...
Nucleotide sequences coding for interleukin polypeptide for use as tool in tissue repairdoi:US7608426 B2Novel mammalian zcyto7 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.Scott R. Presnell...
Some of these supervised learning-based approaches are not mechanistically grounded but choose to investigate mechanisms in post-processing steps63,64,65. Other mechanism-based sequence-to-function models66 predict the binding of individual TFs but do not go beyond that to consider the collective ...
Introduction:Cartilage defects are common pathologies and surgical cartilage repair shows promising results. In its postoperative evaluation, the magnetic resonance observation of cartilage repair tissue (MOCART) score, using different variables to describe the constitution of the cartilage repair tissue and...
13. A method of modifying the phenotype of a Brassica plant seed comprising the steps of growing a Brassica plant having integrated in its genome, or in the genome of a parent thereof, a DNA construct comprising, in the 5' to 3' direction of transcription, a transcription initiation regi...
17. A method for producing a BMP-7 protein, said method comprising the steps of (a) culturing in a suitable culture medium said transformed host cell of claim 13; and (b) isolating and purifying said bone and/or cartilage inductive protein from said culture medium. ...