d, TFs control transcription by directly or indirectly affecting chromatin structure (left), displacing nucleosomes and opening local chromatin (middle) and recruiting and positioning RNA polymerase II (Pol II) (right). Gene regulatory unit with classical (orange) and chromatin-dependent (dark blue)...
In the Fdh-N structure, the Se atom is in close contact with the α-carbon of formate (modelled from the inhibitor position in the FDHH structure) and could directly attack the α-carbon to form an intermediate state to enable α-proton transfer to His197. SeCys could also be important...
47, 48 and 51 contained resistance genes and most of these were predicted to encode resistance to lincosamides, due to presence oflnuCorlnuD(Table3). Antibiotic resistance genes were found in both Victorian and Queensland isolates and in a number of STs. Screening NCBI forLnuCrevealed...
We envision that EvoDiff will expand capabilities in protein engineering beyond the structure-function paradigm toward programmable, sequence-first design.We evaluate our sequence and MSA models – EvoDiff-Seq and EvoDiff-MSA, respectively – across a range of generation tasks to demonstrate their ...
The stacking patterns and distribution regularity of different types of sandbodies are closely related to the fourth-order sequence structure. The distributary channel sandbodies in delta plain facies are mainly developed in EMSQ1, and cut each other and overlap vertically so that their connectivity ...
Structure-to-unknownalignments align a given structure to a sequence with unknown structure. Applications are finding homologous sequences by inferring a consensus structure to a sequence (this is done, for example, in the verification phase of the FASTR package [9]), or finding new family membe...
Interestingly, Golay kernels 10 and 26 have an inner structure, demonstrated by their mathematical connection with Barker sequences of odd length [55] and the recent decompositions of the Golay kernels of lengths 10 [56] and 26 [57] as the product of multilevel Hadamard matrices. In 1969 ...
genome sizes and repeat structure of five environmental strains ofE. colifrom shortIlluminareads were estimated by this method, and total genome sizes corresponded well with those obtained for the same strains by pulsed-field gel electrophoresis. In addition, this approach was applied to read-sets ...
VDOM is a textual virtual representation of the web documents deruved frin the DOM of a website at the time of the snapshot. In order to do this the VDOM provides a rich markup to the textual data in the cleanbody text. Each item will contain its id, the text referenced, start_idx...
Biological sequence clustering is a complicated data clustering problem owing to the high computation costs incurred for pairwise sequence distance calculations through sequence alignments, as well as difficulties in determining parameters for deriving r