d, TFs control transcription by directly or indirectly affecting chromatin structure (left), displacing nucleosomes and opening local chromatin (middle) and recruiting and positioning RNA polymerase II (Pol II)
In the Fdh-N structure, the Se atom is in close contact with the α-carbon of formate (modelled from the inhibitor position in the FDHH structure) and could directly attack the α-carbon to form an intermediate state to enable α-proton transfer to His197. SeCys could also be important...
The detailed sequence of the human X chromosome is published this week, together with a survey of inactivated X genes in females. Females have two Xs and males have one X and a Y; to make the gene dosage equivalent, females inactivate almost an entire chromosome. The X inactivation profile...
RNA sequences evolve more rapidly than the structure they are forming, because their evolutionary behavior follows the structure-function paradigm: RNA molecules with different sequences but same or similar secondary structure are likely to belong to the same functional family, in which the secondary ...
and these partial cDNA sequences are known as EST. Genome sequencing has generated a vast amount of information that can be used for structure and function analysis. A large number of ESTs can be generated from mRNA, and then, these ESTs can be compared with already known sequences in the...
We envision that EvoDiff will expand capabilities in protein engineering beyond the structure-function paradigm toward programmable, sequence-first design.We evaluate our sequence and MSA models – EvoDiff-Seq and EvoDiff-MSA, respectively – across a range of generation tasks to demonstrate their ...
genome sizes and repeat structure of five environmental strains ofE. colifrom shortIlluminareads were estimated by this method, and total genome sizes corresponded well with those obtained for the same strains by pulsed-field gel electrophoresis. In addition, this approach was applied to read-sets ...
The stacking patterns and distribution regularity of different types of sandbodies are closely related to the fourth-order sequence structure. The distributary channel sandbodies in delta plain facies are mainly developed in EMSQ1, and cut each other and overlap vertically so that their connectivity ...
In order to face this challenge, biology and computer science joined forces, exploring solutions that demand sophisticated algorithms and powerful computing devices. As a result, refined solutions have been devised to support several biological subdomains such as protein structure prediction and docking [...
D. Identification of repeat structure in large genomes using repeat probability clouds. Anal. Biochem. 380, 77–83 (2008). Article CAS Google Scholar de Koning, A. P. J., Gu, W., Castoe, T. A., Batzer, M. A. & Pollock, D. D. Repetitive elements may comprise over two-thirds ...