d, TFs control transcription by directly or indirectly affecting chromatin structure (left), displacing nucleosomes and opening local chromatin (middle) and recruiting and positioning RNA polymerase II (Pol II) (right). Gene regulatory unit with classical (orange) and chromatin-dependent (dark blue)...
The detailed sequence of the human X chromosome is published this week, together with a survey of inactivated X genes in females. Females have two Xs and males have one X and a Y; to make the gene dosage equivalent, females inactivate almost an entire chromosome. The X inactivation profile...
In the Fdh-N structure, the Se atom is in close contact with the α-carbon of formate (modelled from the inhibitor position in the FDHH structure) and could directly attack the α-carbon to form an intermediate state to enable α-proton transfer to His197. SeCys could also be important...
To perform the convolutional operations on each time step independently, include a sequence folding layer before the convolutional layers. LSTM layers expect vector sequence input. To restore the sequence structure and reshape the output of the convolutional layers to sequences of feature vectors, inser...
We envision that EvoDiff will expand capabilities in protein engineering beyond the structure-function paradigm toward programmable, sequence-first design.We evaluate our sequence and MSA models – EvoDiff-Seq and EvoDiff-MSA, respectively – across a range of generation tasks to demonstrate their ...
and these partial cDNA sequences are known as EST. Genome sequencing has generated a vast amount of information that can be used for structure and function analysis. A large number of ESTs can be generated from mRNA, and then, these ESTs can be compared with already known sequences in the...
Structure-to-unknownalignments align a given structure to a sequence with unknown structure. Applications are finding homologous sequences by inferring a consensus structure to a sequence (this is done, for example, in the verification phase of the FASTR package [9]), or finding new family membe...
The stacking patterns and distribution regularity of different types of sandbodies are closely related to the fourth-order sequence structure. The distributary channel sandbodies in delta plain facies are mainly developed in EMSQ1, and cut each other and overlap vertically so that their connectivity ...
D. Identification of repeat structure in large genomes using repeat probability clouds. Anal. Biochem. 380, 77–83 (2008). Article CAS Google Scholar de Koning, A. P. J., Gu, W., Castoe, T. A., Batzer, M. A. & Pollock, D. D. Repetitive elements may comprise over two-thirds ...
Here we represent human lives in a way that shares structural similarity to language, and we exploit this similarity to adapt natural language processing techniques to examine the evolution and predictability of human lives based on detailed event sequen