To truly give a sense of scale of possible usage of this type of technologies, one can use an example of a construct which, under even very conservative estimations, would require a massive effort to stop it from collapsing into a gigantic black hole: They had turned galaxies into neat ball...
Although the unmethylated version led to stochastic loss of transcriptional activity, the methylated construct gave rise to stable repression of the nearby promoter for multiple generations, indicating that ZFP57 binding is not only required for the maintenance of epigenetic memory at ICRs but also ...
Gene regulation in the human genome is controlled by distal enhancers that activate specific nearby promoters1. A proposed model for this specificity is that promoters have sequence-encoded preferences for certain enhancers, for example, mediated by inte
(The name comes from the world of functional programming, where this kind of construct is used a lot.) In this case, Unit is used to publish an acknowledgement that the Action is complete, because an Action does not return any information. The Unit type itself has no value; it just ...
We chose the Tet-On system as an example to validate the performance of DeepSEED (Fig.5a). We preserved the miniCMV promoter sequence as well as the tetO sites as ‘seed’ sequences and then generated flanking sequences with DeepSEED. The generator model was trained on the enhancer sequenc...
TheXOR join; several alternatives are merged into one; in our example taskCis enabled when eitherAorBterminates,Figure 7.3E. • TheOR splitpattern is a construct to choose multiple alternatives out of a set. In our example, after completion of taskA, one could activate eitherBorC, or both...
A similar procedure can be followed to construct implicit schemes for multidimensional problems. In this case, however, the expense of solving the equations is greatly increased by the fact that the bandwidth of the equations is much larger since the change in the solution in each cell is relate...
For example, the following BST can be constructed from the sequence {15, 10, 8, 12, 20, 16, 25} and it has the same preorder traversal: Practice this problem The idea is first to construct a BST from the given sequence by inserting keys into the BST one at a time and then compare...
In the natural analysis, because we do not have knowledge of\({\hat{p}}^{0}(S)\)or access to large MSAs generated from\({\hat{p}}^{0}(S)\), ther20metric is subject to much larger estimation error due to the small 10K target MSA, and so we cannot construct the estimation uppe...
Protein ubiquitination regulates a wide range of cellular processes. The degree of protein ubiquitination is determined by the delicate balance between ubiquitin ligase (E3)-mediated ubiquitination and deubiquitinase (DUB)-mediated deubiquitination. In c