This unit provides an overview of the inference of homology from significant similarity, and introduces other units in this chapter that provide more details on effective strategies for identifying homologs.William RUniversity of Virginia School of MedicineCharlottesvillePearson...
Sequence homology refers to the degree of similarity in the genetic sequences of different proteins or molecules. In the context of the provided text, high sequence homology among Neurotrophins (NTs) made it challenging to develop specific antibodies for Brain-Derived Neurotrophic Factor (BDNF). ...
An Introduction to Sequence Similarity ("Homology") Searching Sequence similarity searching, typically with BLAST, is the most widely used and most reliable strategy for characterizing newly determined sequences. Sequ... WR Pearson - Current protocols in bioinformatics / editoral board, Andreas D. Ba...
PyMod 3 - sequence similarity searches, multiple sequence/structure alignments, and homology modeling within PyMOL. bioinformatics pymol-plugin pymol protein-sequences sequence-alignments homology-modeling protein-structures structural-alignments similarity-searches Updated Jan 10, 2025 Python sbl...
HMMER is a software suite for protein sequence similarity searches using probabilistic methods. Previously, HMMER has mainly been available only as a computationally intensive UNIX command-line tool, restricting its use. Recent advances in the software, HMMER3, have resulted in a 100-fold speed gain...
cagnagella and combined the results with transcriptomic and proteomic analyses and a homology searches using proteins detected in Y. evonymella. Results Y. cagnagella genome. The genome size of Y. cagnagella was determined by flow cytometry. Four heads of adult males were used with Ephestia ...
The sequence between SacI and AfeI was replaced with a sequence containing CG-depleted chicken lens δ1-crystallin gene (Sasaki) promoter51, a synthetic intron (pIRESpuro3; Clontech, 631619), an ORF (fusion of Nanoluc-EmGFP), homology arms for library cloning with AgeI and SalI restriction ...
As more sophisticated similarity models incorporate elements of these three-dimensional chemical environments, they have the potential to supplant the use of primary structure homology as the foremost method of data retrieval. 展开 关键词: metric space similarity search bioinformatics 会议名称: 2008 ...
One approach toward determining homology entails the use of sequence-alignment algorithms that maximize the similarity between two sequences. For homology modeling, these alignments could be used to obtain the likely amino-acid correspondence between the sequences. Introduction Sequence alignment identifies...
The NH 2 -terminal sequence suggests that these PGs are made as pre pro-proteins and the secretory propeptide of the PGII precursors shows sequence homology with some other fungal pro-peptides. The expression of the pgaII genes is strongly regulated by the carbon source and the A. tubigensis...