For example, diabetes mellitus results from the absence or ineffectiveness of insulin, and dwarfism from the lack of growth hormone. Thus, simple replacement therapy with recombinant forms of insulin or growth hormone heralded the beginnings of the biotechnology industry. However, nearly all drugs ...
Rhazya stricta(Apocynaceae) is among the most economically important medicinal plants adapted to the arid regions of South Asia and the Middle East. Leaf extracts are prescribed in folk medicine for the treatment of various disorders including diabetes, sore throat, syphilis, helminthiasis, inflammatory...
They also differ for a variety of metabolic traits including obesity, diabetes, and serum cholesterol, triglycerides, and free fatty acids levels [40-51]. The SM/J strain responds more strongly than LG/J to a high-fat diet for these metabolic traits. The two strains also differ for maternal...
yet they do not develop diabetes or hypertension. TheCamelidaefamily are the only mammals that can produce heavy-chain antibodies (HCAbs), a special form of immunoglobulin that lacks the light chain, in contrast to conventional antibodies (Abs)8. HCAbs are smaller and more stable, offering part...
Background: Type 2 diabetes (T2D) is one of the leading causes of mortality and is a public health challenge worldwide. Metformin is the first-choice treatment for T2D; its pharmacokinetics (PK) is facilitated by members of the solute carrier (SLC) superfamily of transporters, it is not met...
(FDA) for SMA treatment [32,38,39]. ASOs can potentially treat many diseases, such as neurodegenerative diseases and diabetes [40,41]. Spinraza (nusinersen), an ASO that blocks ISS-N1, is the first approved SMA therapeutic drug for clinical application. However, it cannot permanently restore...
Defects in the carriers are linked to diseases such as severe obesity, type II diabetes, neonatal myoclonic epilepsy, Amish-type microcephaly and type II citrullinemia [6]. The MCs are unique among transporters for their tripar- tite folding topology [7,8]. Each of the three homologous ...