Avendano, C.; Lafitte, T.; Adjiman, C. S.; Galindo, A.; Müller, E. A.; Jackson, G. SAFT-y Force Field for the Simulation of Molecular Fluids: 2. Coarse-Grained Models of Greenhouse Gases, Refrigerants, and Long
The presented method also relies on the bioinformatic prediction of which missense variants are damaging to filter those that qualify for consideration in the model, although we found similar results with different bioinformatic tools (Figure S11).42,43 Other improvements will involve focusing on ...
In eukaryotes, small nuclear RNAs (snRNAs) function in many fundamental cellular events such as precursor messenger RNA splicing, gene expression regulation, and ribosomal RNA processing. The snRNA activating protein complex (SNAPc) exclusively recognize
It is well-known that age is a risk factor for a range of diseases, such as coronary artery disease, hypertension, diabetes, and fatty liver [30]. The risk of cardiovascular adverse events in young people is much lower than that in elderly people. Another predictor was the duration of ...
yet they do not develop diabetes or hypertension. TheCamelidaefamily are the only mammals that can produce heavy-chain antibodies (HCAbs), a special form of immunoglobulin that lacks the light chain, in contrast to conventional antibodies (Abs)8. HCAbs are smaller and more stable, offering part...
The higher correlation with UTIs may attributed to (1) patients’ underlying health conditions (i.e. diabetes, kidney stones) and access to hospitals or public facilities in community; (2) some exogenous input, such as international tourists or objects; (3) the ability of older adults to ...
They also differ for a variety of metabolic traits including obesity, diabetes, and serum cholesterol, triglycerides, and free fatty acids levels [40-51]. The SM/J strain responds more strongly than LG/J to a high-fat diet for these metabolic traits. The two strains also differ for maternal...
We have found that alterations in isoform ratio in skeletal muscle were associated with hyperinsulinemia rather than diabetes (15). Similar results have been found in the rhesus monkey (16). Along these lines, Sell and co-workers (17) have shown that alternative splicing of the IR gene is ...
Elofsson and Von Heijne, “Membrane Protein Structure: Prediction Versus Reality.” Annu Rev Biochem, 76:125-140 (2007). González-Reyes, et al., “Cleavage of the Human Respiratory Syncytial Virus Fusion Protein at Two Distinct Sites Is Required for Activation of Membrane Fusion.” Proceedings...
The subject matter of the invention is directed to a single-chain insulin analog that is used to treat diabetes by gene therapy methods.