Lateral septal nucleusPrefrontal cortexRatDepressionStressSeveral clinically effective antidepressants increase the neuronal firing rate in the lateral septal nucleus (LSN), a forebrain structure that is anatomically related to medial prefrontal cortex (mPFC) regions. mPFC function is related to depression ...
The septal nucleus also provides the major subcortical input to CA3. As with thedentate gyrus, the septal projection originates mainly in themedial septal nucleusand nucleus of thediagonal band of Brocaand terminates both in stratum oriens and stratum radiatum (Fig. 5.6D; (Schwegler et al., ...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook septal Thesaurus Medical Encyclopedia Wikipedia Related to septal:atrial septal defect,septal area,Septal myectomy,Septal nuclei sep·tal (sĕp′təl) adj. ...
For example, when the septal nucleus is electrically stimulated for brief periods, animals generally reduce their activity, and may lay down as if resting, and may even become unresponsive or oblivious to threat or other disturbances in the environment (MacLean, 1990). If the amygdala is destroye...
Neurons of the medial septal nucleus are important in regulating the physiological activity of the hippocampus. If intraseptal injection of putative neurotransmitter substances affects the turnover rate of hippocampal acetylcholine, then concomitant changes would be expected in the electrophysiologic activity...
thereby promoting depressive-like behaviors32. Astrocytic oxytocin receptors in the lateral part of the central nucleus of the amygdala (CeA) enhance GABAergic inputs to neurons in the medial CeA and increase anxiolytic behaviors33. We hypothesize that LS astrocytes, together with neurons, regulate ...
In the dorsal septal nucleus, two pharmacological distinct pathways were postulated: The first, an afferent collateral pathway in which the interneurons appear to be cholinergic. The second, a recurrent collateral pathway in which the interneurons appear to utilize GABA. In the lateral septal nucleus...
General properties.Every cell has two principal parts—the nucleus and the cytoplasm. Within each of these it is possible to distinguish certain substructures, which differ in shape, size, internal structure, chemical properties, and function. Some of these, called organoids, are vital to the cel...
The effects of nimodipine were investigated on performance of rats with medial septal nucleus lesions in the Morris water maze. The paradigm began with 10
In the immunolesioned rat, only a few cells remained in the medial septal nucleus (MS) and diagonal band of Broca (DB). Bar=300 μm. 2.5. Light microscopic analysis Our previous study [44] analyzed changes in the number and distribution of NPY-containing somata within the hilus of the ...