A recent RCT, monitored to ensure protocol and MAP target compliance, compared a “permissive hypotension” (MAP 60–65 mm Hg) group with a “usual care” group that received vasopressors and MAP targets set by the treating physician in patients aged 65 years and older with septic shock [82...
However, current international guidelines for the management of sepsis and septic shock from the Surviving Sepsis Campaign advise against the use of intravenous immunoglobulins (IVIGs) in these conditions [94]. This recommendation was graded as weak, with low quality of evidence, and was based large...
Until recently, adult guidelines have recommended early goal-directed therapy (EGDT) based on the protocol published by Rivers et al. [212]. This recommendation described the use of a series of “goals” that included CVP and Scvo2. This approach is no longer recommended following a failure ...
INTRODUCTION AND OBJECTIVES In an effort to design a research study for prostate biopsy prophylaxis, we needed a protocol that would be accepted by most urologists. Our goal was to assess the practice pattern for prostate biopsy prophylaxis in order to tailor a study that urologists would agree ...
All methods are carried out in accordance with relevant guidelines and regulations. Consent for publication Not applicable to the study protocol presented in this manuscript. Competing interests The authors declare no competing interests.Additional information Publisher’s Note Springer Nature remains neutral...
Improvement interventions often target the person through education and training, protocol dissemination or recommend the use of a tool or technology, such as an IT template or early warning scores [49,50,51]. Educational interventions alone are considered weak as they depend on memory of training...
The current study was reported in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology Guidelines. This study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The trial protocol was approved by the Central Institutional Review Board ...
Challenge2: Bundle Compliance and Protocolized Sepsis Care. The authors of the one-hour bundle state, "The compelling nature of the evidence in the literature … has demonstrated an association between compliance with bundles ...
The rationale for starting an insulin protocol with a blood glucose level of 180 mg/dL or higher and targeting a blood glucose level of 144–180 mg/dL is based on the NICE-SUGAR trial—the largest study among the RCTs that validated the target level of blood glucose in ICU patients. The...
1. Following initial stabilization of patients with severe sepsis, maintain blood glucose <150 mg/dl (8.3 mmol/l). Studies supporting the role of glycemic control have used continuous infusion of insulin and glucose. With this protocol, glucose should be monitored frequently after initiation of th...