What is knownIn light of the individual variability of septic patients, traditional clinical trial results currently have an inability to predict the response to an intervention at the level of an individual. Similarly, clinical practice guidelines are based upon a composite of overall best practice ...
account for approximately eight million deaths a year worldwide [12]. These deaths are not officially counted as deaths attributable to sepsis, though all of these infectious diseases undoubtedly share sepsis as a common final pathway. As noted above, extensive data regarding the epidemiology of sev...
Implemented changes including a revised sepsis pathway and raising awareness led to some positive changes. However, upon re‐auditing there was no significant change in the number of children being overdiagnosed. Conclusions: Initial audit results supported our hypothesis that children were ...
In conclusion, our study revealed that sepsis-related damage to the intestinal mucosal barrier may involve processes such as cytokine-cytokine receptor interaction, Th1 and Th2 cell differentiation, viral protein interactions with cytokines and their receptors, and the IL-17 signaling pathway. TBX21,...
Gentiopicroside (GENT) protects against sepsis induced by lipopolysaccharide (LPS) through the NF-κB signaling pathway. Ann Transl Med 2019;7(23):731. doi: 10.21037/atm.2019.11.126 Correspondence to: Yongjun Wang; Qianqian Liang. Institute of Spine, Longhua Hospital, Shanghai University of ...
the greater the likelihood of systemic infection and sepsis. Given its high sensitivity to most types of infections, procalcitonin is widely regarded as the most sensitive biomarker to help diagnose (or rule out) bacterial sepsis. Global guidelines also recommend its use as a tool to optimize anti...
Sepsis is an under-recognized global health concern with severe consequences to both the patient as an individual (high mortality rate), and the health care system as a whole (high annual costs). Of particular concern is the elderly population, in whom sepsis is a major cause of morbidity an...
Just as in cancer therapeutics, another frontier we see is the use of more rational combinations of vasopressors each in lower doses and given according to specific patient vasopressor pathway deficits, such as vasopressin for vasopressin deficiency and angiotensin II for ACE deficiency in ARDS compli...
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The NICE-SUGAR (Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation) Study: statistical analysis plan. Crit. Care Resusc. 11, 46–57 (2009). PubMed Google Scholar Kreymann, K. G. et al. ESPEN guidelines on enteral nutrition: intensive care. Clin. ...