Sepsis has recently been redefined as acute organ dysfunction due to infection. The ED plays a critical role in identifying patients with sepsis. This is challenging due to the heterogeneity of the syndrome, and the lack of an objective standard diagnostic test. While overall mortality rates from...
Sepsis has recently been redefined as a syndrome that causes life-threatening multiple organ dysfunction due to disordered host response to an infection1. The brain is one of the most frequently injured organs in sepsis, with an incidence rate of over 50%2,3. Brain injury in sepsis clinically...
Thus, sepsis has been now redefined as a life-threatening organ dysfunction due to a dysregulated response of the host to infection (Singer et al., 2016). A major hurdle in the clinical management of septic patients is the lack of the effective treatment (Riedemann et al., 2003, Hattori ...
Quite recently, the third international consensus definitions have been reviewed for sepsis and septic shock. In short, sepsis has been now redefined as a life-threatening organ dysfunction due to a dysregulated response of the host to infection5. However, the pathophysiological process in the ...
To advance understanding of sepsis and septic shock, the task force convened by the European Society of Intensive Care Medicine and the Society of Critical Care Medicine introduced the "Sepsis-3" definition between 2014 and 2015 [1]. This update redefined sepsis as life-threatening organ dysfuncti...
Early diagnosis is a prerequisite for improving the curative ratio of sepsis, and early intervention greatly reduces the incidence of organ dysfunction and mortality. However, until recently, sepsis has been finely defined. In 1991 [21], experts in the field of critical care medicine jointly elabor...
The systemic inflammatory response caused by severe infection was defined as sepsis by the American College of Chest Physicians/Society of Critical Care Medicine in 1992 [3]. Moreover, sepsis was redefined as life-threatening organ dysfunction caused by a dysregulated host response to infection, ...
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to quintessential infection [1, 2], and has been described as the quintessential medical disorder in our contemporary era. Sepsis is a leading cause of morbidity and mortality in hospitalized patients despite improve...
recently redefined sepsis as “severe endothelial dysfunction syndrome in response to intravascular and extravascular infection”6,7. All blood vessels of the body are lined with a single layer of endothelial cells. These cells are the contact-point between blood and the body and as such they ...
(sepsis 3.0) was released, with a redefined standard for sepsis that better reflects organ dysfunction and response dysregulation [44]. In 2017, apoptosis-induced lymphopenia was re-emphasized as a frequent process during sepsis and severe injuries (e.g., burns, major surgery, and trauma) [16...