Regarding its function as a “molecular scissor”, whether ADAM10 works for beneficial or harmful effects depends on the substrates it cleaves on different cell types under different pathological conditions (Table1). ADAM10, as a therapeutic target, may also cause toxic side effects due to the lon...
This distinction can be challenging to attribute solely to host factors, such as the immaturity of the host´s immune system in premature infants. The retrospective design of this study is a limitation, due to the lack of possibility to control missing data or to re-test cultures for ...
dynamic assessment to guide fluid therapy was associated with reduced mortality (RR 0.59; 95% CI 0.42–0.83), ICU length of stay (MD −1.16 days; 95% CI −1.97 to −0.36), and
epidermidis colonization was associated with more severe AD disease [82], which may be due to S100A8/A9-dependent alterations of the skin barrier proteins [83]. Antiviral activities of S. epidermidis have also been documented. For instance, nasal commensal S. epidermidis can act as a frontline...
Furthermore, the consistent findings by a prospective, observational study conducted in sepsis in the ICU to measure antibiotic bacterial resistance have shown that patients with MDRO significantly received inadequate empirical antibiotics more frequently and long ICU-LOS than patients with sepsis due to ...
(5) Due to the physical condition of neonates, blood culture volumes are limited (often just one milliliter of blood). This might have led to a higher probability of false negative results. Moreover, the bacterium found might not have been automatically causative for infection. (6) We used...