Sepsis, as a principal cause of mortality in emergency and intensive care settings worldwide, sepsis is responsible for numerous new cases each year, marked by a notably high mortality rate25. This consistently
We included all adult patients admitted with a culture-confirmed UTI, pneumonia, or sepsis as principal diagnosis, or as a secondary diagnosis in the setting of respiratory failure. Patients with hospital acquired infections or transfers from other acute facilities were excluded. IET was defined as ...
Sepsis is a major cause of morbidity and mortality in the United States and remains the leading cause of death in children worldwide. Children with sepsis and progressive septic shock present a unique set of challenges for clinicians as the diagnosis, initial fluid resuscitation, and subsequent hem...
AInnate immune dysfunction in sepsis.BAdaptive immune dysfunction in sepsis. When septic insults happen, both the innate and adaptive immune responses are drastically changed. Shortly after detection of an infectious agent, the innate immune cells attempt to clear the overwhelming infection as quickly ...
To be included in the study sample, patients were required to have a principal diagnosis of sepsis present on admission. ICD-10 codes used to identify sepsis are provided in Appendix 1. Outcome variables The patient outcome variables of interest were in-hospital mortality, 60-day mortality, 60...
Until the latter part of the 20th century, the principal research focus and mechanistic understanding of sepsis pathogenesis was directed toward controlling the spread of pathogens. This perspective shifted to the immune system in the early 1980s, when macrophage activation and release of tumor necrosi...
diagnosis and treatment. Due to their unique properties, including diversity, ease of synthesis, biocompatibility, high specificity, and excellent pharmacological efficacy, peptides hold great potential as part of nanotechnology approaches against sepsis. Herein, we present a comprehensive and up-to-date...
diagnosis and management. Development of nanosensors based on electrochemical, immunological or magnetic principals provide highly sensitive, selective and rapid detection of sepsis biomarkers such as procalcitonin and C-reactive protein and are reviewed extensively. Nanoparticle-based drug delivery of ...
with 28-day survival (adjusted OR 0.68 [95% CI 0.51, 0.91]) and 1-year survival (adjusted OR 0.74 [95% CI 0.59, 0.93]). Thus, persistent lymphopenia on the fourth day after sepsis diagnosis predicts early and late mortality and may serve as a biomarker for sepsis-induced ...
P8 LightCycler SeptiFast assay as a tool for the rapid diagnosis of sepsis in patients receiving antimicrobial therapy Adriana Vince, Snjezana Zidovec Lepej, Bruno Barsic, Davorka Dusek, Zdravko Mitrovic, Ranka Serventi Seiwerth, Boris Labar Department of Molecular Diagnostics and Flow Cytometry,...