This article presents updated definitions of and clinical criteria for diagnosing sepsis and septic shock based on recommendations from an expert task
Population selection criteria As illustrated in Fig. 1, a total of 76,943 intensive care unit (ICU) admissions were recorded in the MIMIC-IV database. Sepsis was diagnosed according to the sepsis-3 criteria, wherein patients with documented or suspected infection and an acute change in total ...
Sepsis was diagnosed according to sepsis-3 criteria [1], sepsis-relevant ICD-9 codes (99,591—99,592), or ICD-10 codes (R652, R6520 and R6521) [14, 15]. The outcome variable was death from any cause during 28-day after ICU admission, and PaO2/FiO2 was the exposure variable (...
Adult patients meeting the Sepsis 3.0 criteria [79] were recruited from the Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine. Healthy adult volunteers were recruited as control subjects. The study protocols were approved by the Human Research Ethics...
Sepsis was identified using Sepsis-3 criteria. SAE was defined as having at least two GCS measurements of either < 7 for patients with endotracheal tubes, tracheostomies, or aphasia, or < 12 for the remaining patients within the 7 days of sepsis. Dementia at 3 months and 1 year was ...
Above, we can see that, as we change the criteria used to define sepsis, the percentage of patients who satisfy the criteria decreases (blue bars) and the percent mortality of that cohort increases (red bars). For more detail please see the paper. Acknowledgement If you find the code usefu...
Clinical state labels were determined using Sepsis-3 criteria. Full size image Table 1 Performance metrics for each of the four evaluated strategies for early prediction of septic shock. Full size table The major performance differences between our pre-shock state-based method vs the Cox method as...
Results Patients Among 1 309 025 patient encounters in the SENECA derivation cohort (eFigure 3 in the Supplement), 87 844 patients (6.7%) had suspected infection within 6 hours of hospital presentation and 20 189 met Sepsis-3 criteria (eTable 5 in the Supplement). The mean SOFA ...
screening tool for sepsis [40,41,42]. The results have been contradictory as to its usefulness. Studies have shown that qSOFA is more specific but less sensitive than having two of four SIRS criteria for early identification of infection induced organ dysfunction [40,41,42,43]. Neither SIRS...
Thirty adult ICU septic patients, as defined by the Sepsis-3 criteria published by the ESICM-SCCM Sepsis Redefinitions Task Force [29], were enrolled non-consecutively after the initial resuscitation. Written informed consent was obtained from the patients or their legal representatives. Exclusion crit...