29,30 The biophysical principles of sensory function in the gastrointestinal tract are like those found elsewhere in the body. Each sensory neuron has at least one neurite with a generator region that converts a
GoF, gain of function; JAK1, Janus kinase 1. In light of our findings that both chemical denervation via i.g. RTX (Figures 3L–3Q) and sensory neuron-intrinsic deletion of Jak1 (Figures 4C–4G) results in enhanced allergic lung inflammation, we sought to test whether RTX-mediated denervat...
control neuron cultures we determined (i) mitochondrial DNA (mtDNA)/nuclear DNA (nDNA) ratio using qRT-PCR, and (ii) mitochondrial respiration (oxygen consumption rate; OCR) assessed using the Seahorse XF24. Finally, specific inhibitors and siRNAs against IGF-1-activated signaling cascades were ...
Therefore, emulating the biological processes from the level of sensory neuron would fundamentally achieve biological perceptual capabilities. Artificial sensory neuron development can benefit from an improved understanding of sensory processing in biology. One notable advantage of the biological sensory systems...
Specifically, are channel proteins arranged in parallel and function independently during perception, or are these channel proteins arranged in functional sensory networks. We propose a hierarchal functional arrangement of channels within polymodal sensory neurons that incorporates aspects of both parallel and...
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The main objective of this study is to develop a function-based model to systematically map sensory integration along the processing hierarchy. In pursuit of this aim, we evaluate the capability of the proposed sensory integration model to delineate known sensory processing streams, discern diverse st...
(that is, if membrane potential reaches a threshold), the neuron will fire an action potential. In most cases, the correct stimulus impinging on a sensory receptor will drive membrane potential in a positive direction, although for some receptors, such as those in the visual system, this is ...
hyperalgesia if the variant causes gain of function6(Fig. 5a,i). Although defects in channel conductance and excitability of sensory neurons have been proposed as disease mechanisms in cellular and animal models6,45,46,47, the circuit-level consequences have not yet been explored in a human ...
Another general principle is that the intensity of the stimulus is encoded as the amplitude of the electrical signal passing along the sensory neuron. In most cases, this means the action potentials propagating along the sensory axon, with more action potentials per second representing a stronger ...