α-Synuclein proximity ligation assay (PLA) has proved a sensitive technique for detection of non-Lewy body α-synuclein aggregate pathology. Here, we describe the MJF-14 PLA, a new PLA towards aggregated α-synuclein with unprecedented specificity, usin
57. Specific irradiation conditions generate the fluorescence signal from cells, and drive the magnetically sensitive photocycle57. However, no specificity and reasoning for crucial parameters of photoexcitation are discussed, e.g. light wavelength, power, irradiance, pulse duration57....
While the transcription factor specificity protein 3 (SP3) has been shown to confer differential sensitivity to SM by regulating TNF expression [62]. However, TNF production was not the only limiting factor, since addition of exogenous TNF only partially reversed resistance to SM treatment in three...
However, the reproducibility, sensitivity and specificity vary considerably according to the antibody, antigen retrieval and amplification systems, and the scoring method and cutpoints used (Mino-Kenudson et al, 2010; Camidge et al, 2011b). Here we calculate the cost-effectiveness of marker ...
For strategy 3, the accuracy was 72.65 ± 7.96% (sensitivity 0.72 ± 0.1, specificity 0.75 ± 0.11, PPV 0.72 ± 0.14, NPV 0.74 ± 0.11) for GIG-ICA and 66.26 ± 7.23% (sensitivity 0.65 ± 0.09, specificity 0.68 ± 0.1, PPV 0.65 ...
α-Synuclein proximity ligation assay (PLA) has proved a sensitive technique for detection of non-Lewy body α-synuclein aggregate pathology. Here, we describe the MJF-14 PLA, a new PLA towards aggregated α-synuclein with unprecedented specificity, usin
In each graph, the velocity of the object in the speed-changes event vs. the velocity of the object in the constant speed event as a function of time was plotted. The black line represents the speed change stimuli, whereas the gray line represents the constant speed stimuli. Full size ...
(1997). Specificity of CEO human capital and compensation. Strategic Management Journal, 18(11), 895–920. Article Google Scholar Hoi, C. K. S., Wu, Q., & Zhang, H. (2019). Does social capital mitigate agency problems? Evidence from Chief Executive Officer (CEO) compensation. Journal...
(step 1: value identification). Notably, domain-specificity may include the possibility that the perceived morality of values differ between domains. Thus, in business compared to medicine, it is likely that other values are deemed important and shared values might cluster differently. This relates ...
by incorporating a radioactive component into the peptide or used to detect antibodies specifically reactive with the peptide. Typically a detectable label is attached to a probe or a molecule with defined binding characteristics (e.g., a polypeptide with a known binding specificity or a polynucleot...