Mechanism ofAction:AGI stimulantthat has a direct effect on intestinal smooth musculature by stimulating the intramuralnerve plexus.TherapeuticEffect:Increasesperistalsisand promotes laxative effect. Pharmacokinetics: RouteOnsetPeakDuration PO6-12 hrN/AN/A ...
This typically occurs in severe anemias of precipitous onset. Chronic anemia can cause atrophy of centrilobular hepatocytes, which results in dilation and congestion of sinusoids (Fig. 8-37). Livers from animals with severe anemia, whether acute or chronic, typically have an enhanced lobular ...