18 MICROPARTICLES INDUCE ENDOTHELIAL CELL SENESCENCE AND CELL CYCLE ARREST THROUGH REDOX-SENSITIVE PROCESSESBackground: Aging is a primary risk factor for the development of cardiovascular disease and is associated with impaired endothelial function. In chronic disease states including hypertension these ag...
Cellular senescence refers to a state of stable cell cycle arrest in which proliferating cells become resistant to growth-promoting stimuli, typically in response to DNA damage. Senescence was first described by Leonard Hayflick upon the observation that human fetal fibroblasts eventually stopped dividing...
Cellular senescence is a state of stable cell cycle arrest under which cells remain metabolically active, but no longer divide and do not respond to growth-promoting stimuli. Senescence is triggered by a variety of cellular stressors. These include environmental factors like ionizing radiation or exp...
Senescence is a state of permanent cell cycle arrest. Cellular senescence can promote tissue remodelling but can negatively affect regenerative capacities of tissues and contribute to inflammation and the progression of cancer and ageing-related dis
Cellular senescence represents an irreversible state of cell-cycle arrest during which cells secrete senescence-associated secretory phenotypes, including inflammatory factors and chemokines. Additionally, these cells exhibit an apoptotic resistance phen
Untreated T47D cells progressed through the various cell cycle stages, as indicated by the expression of cyclin A2 and B1. The lack of cyclin expression in the treated T47D cells is consistent with cell cycle arrest in senesc...
Cellular senescenceis a state of stablecell cycle arrestassociated with an inflammatory secretory phenotype. Cellular senescence can be triggered by a variety of stresses such as oncogenic stress, DNA damage, drug treatment, and others. Since senescence puts a brake oncell proliferation, it is though...
Interlinked and fundamental aging processes appear to be a root-cause contributor to many disorders and diseases. One such process is cellular senescence, which entails a state of cell cycle arrest in response to damaging stimuli. Senescent cells can ari
Irradiation of Adult Human Dental Pulp Stem Cells Provokes Activation of p53, Cell Cycle Arrest, and Senescence but Not Apoptosis.Adult human dental pulp contains stem cells (DPSCs) that are capable of differentiation into osteoblasts, odontoblasts, adipocytes, and neuronal-like cells. Because these...
De novo pyrimidine nucleoside biosynthesis depends on CIII via ubiquinone, which functions as the electron acceptor for the mitochondrial DHODH enzyme12. In cultured cells, the blockade of DHODH or CIII can trigger p53 activation, replication stress, and cell cycle arrest due to compromised pyrimidin...