“A Semi-Synthetic Approach to Olefinic Analogs of Amino Acid One (MeBMT) in Cyclosporin A.” Tetrahedron Letters, 30, 32, 4215-4218 (1989). ;, 30, 32, 4215-4218 (1989).A Semi-Synthetic Approach To Olefinic Analogs Of Amino Acid One (MeBMT) In Cyclosporin A. Park, et al. ...
Synthetic biology has allowed for the industrial production of supply-limited sesquiterpenoids such as the antimalarial drug artemisinin and β-farnesene. One of the only unmodified animal products used in medicine is squalene, a triterpenoid derived from shark liver oil, which when formulated into an...
In our semi-synthetic modifications to prepare aristolactam analogs,the aristolochic acids were first converted to their lactams.The purified aristolochic acids were hydrogenated in ethanolic solution under 40psi hydrogen in presence of Pd/C catalyst,over-night at room temperature.The amino ...
To improve the production ratio for doramectin, the aveC gene was subjected to iterative rounds of semi-synthetic DNA shuffling. Libraries of shuffled aveC gene variants were transformed into S. avermitilis, screened using a miniaturized 96-well growth and production format, and analyzed by high ...
Semi-synthetic preparation of human insulinHuman insulin is semi-synthetically prepared using a novel method comprising the preparation of a modified human insulin of the general formula wherein R = H or an enzymatically separable sugar residue or an ester thereof, and R = an enzymatically ...
Amino acid sequences of VH and VL CDRs of antibodies selected from the Nkuku library. Asterisks (*) denote clones which have high probability of having been derived from the portion of the library into which synthetic CDR3s were introduced. The entire H chain of clone C31 was absent, but ...
a, Semi- synthesis of artemisinin from microbially produced artemisinic acid. Compounds in square brackets denote intermediates detected but not isolated. b, HPLC ultraviolet traces of crude, partially purified and purified semi- synthetic artemisinin and commercial samples of plant-derived artemisinin. ...
To rule out the possibility that these low plasma cystine concentrations were the result of a reduced cystine biosynthesis due to a lack of methionine, a substrate of transsulfuration pathway, we studied premature on infusion of a mixture of synthetic l -amino acids free from cystine. Despite ...
Semi-synthetic glycopeptides with antibiotic activity 发明人: CHU DANIEL;PREOBRAZHENSKAYA MARIA N.;PRINTSEVSKAYA SVETLANA S.;OLSUFYEVA EUGENIA N. 申请人: 申请日期: 2006-02-24 申请公布日期: 2006-12-07 代理机构: 代理人: 地址: 摘要: Semi-synthetic glycopeptides having antibacterial activity...
摘要：Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of the desmethyl- vancomycin scaffold, in particular, acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety ...