Hypothetical mechanism of semaglutide action in PTZ-kindled mice. PTZ, pentylenetetrazole; NLRP3, NLR family pyrin domain containing 3; ASC, apoptosis-associated speck-like protein; GLP-1R, glucagon like peptide-1. These findings were in line with previous studies indicating that GLP-1 analogues ...
Figure 6.Schematic representation of the possible mechanism mediating the effect of semaglutide in improving/preventing fibrosis progression in MASLD. Exosome release induces a decrease in several proteins involved in ECM deposition (α-SMA, ph SMAD2, CTGF, Vimentin, COL1A1, and EGFR), resulting in...