How does Retevmo work (mechanism of action)? Retevmo is a type of medicine called a kinase inhibitor. It blocks the action of RET. RET sends signals to cells to tell them to grow. When there is a RET fusion on a cancer cell, cells can grow quickly, which causes cancer to grow and ...
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Based on data from animal reproduction studies and its mechanism of action, Retevmo can cause fetal harm when administered to a pregnant woman. Administration of selpercatinib to pregnant rats during org...
Receptor tyrosine kinase fusions as an actionable resistance mechanism to EGFR TKIs in EGFR-mutant non-small- cell lung cancer. Trends Cancer. 2019;5(11):677–692. doi:10.1016/j.trecan.2019.09.008 16. Zhou C, Solomon B, Loong HH, et al. First-line selpercatinib or chemotherapy and ...
Moreover, the per-residue free energy decomposition analysis unveils that Tyr806 at the hinge region plays an important role in the binding of selpercatinib through hydrophobic interactions. This study will provide useful information for understanding the mechanism of selpercatinib resistance to the ...
Receptor tyrosine kinase fusions as an actionable resistance mechanism to EGFR TKIs in EGFR-mutant non-small- cell lung cancer. Trends Cancer. 2019;5(11):677–692. doi:10.1016/j.trecan.2019.09.008 16. Zhou C, Solomon B, Loong HH, et al. First-line selpercatinib or chemotherapy and ...