According to the ego-depletion account of loss of self-control, self-control is, or depends on, a depletable resource. Advocates of this account have argued that what is depleted is actually glucose. However, there is experimental evidence that indicates that glucose replenishment is not ...
Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSC and potentially also in leukemic stem cells. Besides pathways such as Wnt signaling, Hedgehog signaling and Notch signaling, transcription factors (FoxOs) and cell fate determinants may also ...
System innovation and self-organization Myostatin is well established as a negative regulator of skeletal muscle growth, but its role in the heart is controversial. Our goal in this study was to ... S Kuramochi,K Kasai - 《Memoirs of the Faculty of Engineering Tamagawa University》 被引量: ...
During in vitro cultivation, keratinocytes isolated from the basal layer of the epidermis give rise to three types of clones: holoclones, meroclones, and paraclones [14, 15]. Holoclone is the clone originated from the stem cell and is endowed with the highest proliferative and self-renewing ...
University of Florida College of Medicine, Gainesville, FL, USA; 5Department of Psychology, University of Florida, Gainesville, FL, USA Poor decision making and elevated risk taking, particularly during adolescence, have been strongly linked to drug use; however the causal relationships among these ...
Liposomes containing only donor-labeled peptides served as the no-FRET control. All experiments were performed at least three times and average results are given. Energy transfer E was calculated by means of donor fluorescence intensity at 525 nm in the absence and presence of the acceptor ...
T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Disclosure of potential conflicts of interest is found at the end of this article. WL Tam,CY Lim,J Han,... - 《Stem Cells》 被引量: 353发表: 2010年 Mole...
At hour 4, TIAF1 effectively blocked TGF-b1-mediated nuclear accumu- lation of Smad4 (o10% nuclear localization) and Smad2/3 (35–40% nuclear localization) (Figure 1g). Similar results were observed at hour 8. In control ECFP cells, TGF-b1- induced nuclear accumulation of Smads was ...
Mechanistically, we found that Myc represses Miz1-mediated expression of CCAAT/enhancer-binding protein α (Cebpα) and Cebpδ, thus playing an important role in the pathogenesis of AML by maintaining the undifferentiated state and self-renewal capacity of LSCs. Visual Abstract Download: Download ...
Human stem cells are undifferentiated cells with the capacity for self-renewal and differentiation into distinct cell lineages, playing important role in the development and maintenance of diverse tissues and organs. The microenvironment of stem cell pro