We now report a novel 2-step PRIT platform using Self-Assembling and DisAssembling (SADA) domains that induce rapid elimination of unbound antibody without clearing agent (CA), allowing for tumor specific delivery of 177Lu and 225Ac isotopes. Methods: Tandem bispecific antibody (BsAb) fragments ...
In nature, self-assembling and disassembling complexes of proteins and nucleic acids bound to a variety of ligands perform intricate and diverse dynamic fu... P Yin,HMT Choi,CR Calvert,... - 《Nature》 被引量: 1020发表: 2008年 Controlled Folding of Micrometer-Size Structures Several types of...
All these systems require manual input, such as a human operator or a control station, to determine and inform the robots when to start assem- bling/disassembling and what behaviour to perform for different problems and scenarios. 3 Methodology of the Hyper-heuristics Framework We first introduce...
The knob and the screen coexist, allowing players to take into account the functionality while entertaining, and developed a spring pin connection method, automatic alignment, greatly reducing the risk of cable and PCB damage when disassembling and assembling the upper cover and liner.We separate ...
In the present work, we explored how a known β-sheet-disassembling amino acid, proline (P), affects the self-assembly and gelation properties of amphipathic peptides. For this purpose, we modified the backbone of a known β-sheet-forming peptide, FEFKFEFK (F8, F = phenylalanine, E = ...
The procedure for disassembling the crane, with full folding first of the arm and then of the tower, involves carrying out the erection operations described, in reverse. In this way a crane has been created with a composite tower and automatic erection, whose tower is composed of at least th...
Drug molecules are in general encapsulated physically or by chemical conjugation, and they can be released by the disassembling of nanostructures or the cleavage of conjugated bonds. For example, Ding et al. physically encapsulated 10-hydroxycamptothecin (HCPT) in hydrophobic regions of self-assembling...
1 and illustrating a portion of the arrangement for disassembling the components of the water inlet screen assembly. FIG. 6 is a view similar to FIG. 5 and illustrating another portion of the arrangement for disassembling the components of the water inlet screen assembly. FIG. 7 is a view...
Abstract 1391: Self-assembling and disassembling bispecific antibody platform for pretargeted radioimmunotherapy against GPA33 in a xenograft model of colorectal peritoneal carcinomatosisObjectives: There is increasing interest in the potential role of radioimmunotherapy in the treatment of peritoneal ...
The utility model provides a crawler crane mainframe rear counterweight self-assembling and disassembling device, which comprises a rear counterweight lifting frame, a main platform, a rear counterweight pallet, a hydraulic cylinder and a hoisting plate. One end of the rear counterweight lifting frame...